Remamox
Generic Name
Amoxicillin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remamox 125 mg suspension | ৳ 45.50 | N/A |
Description
Overview of the medicine
Remamox 125 mg Suspension is an antibiotic belonging to the penicillin group. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg (10-20 ml of 125 mg/5 ml suspension) every 8 hours, or as directed by physician.
Children
20-50 mg/kg/day in divided doses every 8 hours, or as directed by physician. For example, children 3-9 months: 1.25 ml (31.25 mg) three times daily. Children 10-14 months: 2.5 ml (62.5 mg) three times daily. Children 1-5 years: 5 ml (125 mg) three times daily. Children 5-10 years: 10 ml (250 mg) three times daily.
Renal_impairment
Dosage adjustment is required for patients with severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Take orally, with or without food. Shake the bottle well before each use. Use the provided measuring device for accurate dosing.
Mechanism of Action
Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Primarily excreted unchanged by the kidneys (50-70% within 6 hours).
Half life
1 to 1.5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; bioavailability is 70-90%. Peak plasma concentrations are reached in 1-2 hours.
Metabolism
Limited metabolism; approximately 10-25% is metabolized to an inactive penicilloic acid.
Side Effects
Contraindications
- Hypersensitivity to penicillin or any other beta-lactam antibiotics
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
May increase the anticoagulant effect.
Allopurinol
May increase the incidence of skin rash.
Methotrexate
May reduce methotrexate excretion, leading to increased toxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (rarely significant).
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
Symptoms of overdose include gastrointestinal effects (nausea, vomiting, diarrhea) and disturbances in fluid and electrolyte balance. In severe cases, renal impairment, crystalluria, or convulsions may occur. Management involves gastric lavage, symptomatic treatment, and supportive measures. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy, but use with caution and only if clearly needed. Amoxicillin is excreted in breast milk; use with caution in nursing mothers, monitoring for potential adverse effects in the infant.
Side Effects
Contraindications
- Hypersensitivity to penicillin or any other beta-lactam antibiotics
- Infectious mononucleosis (increased risk of rash)
Drug Interactions
Warfarin
May increase the anticoagulant effect.
Allopurinol
May increase the incidence of skin rash.
Methotrexate
May reduce methotrexate excretion, leading to increased toxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives (rarely significant).
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
Symptoms of overdose include gastrointestinal effects (nausea, vomiting, diarrhea) and disturbances in fluid and electrolyte balance. In severe cases, renal impairment, crystalluria, or convulsions may occur. Management involves gastric lavage, symptomatic treatment, and supportive measures. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy, but use with caution and only if clearly needed. Amoxicillin is excreted in breast milk; use with caution in nursing mothers, monitoring for potential adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years for unreconstituted powder. Reconstituted suspension is stable for 7-14 days when refrigerated.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Amoxicillin has been extensively studied in numerous clinical trials for its efficacy and safety in various bacterial infections, confirming its role as a first-line antibiotic for many indications.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or during prolonged treatment)
- Renal function tests (in patients with renal impairment)
- Complete blood count (in patients receiving prolonged high-dose therapy)
Doctor Notes
- Counsel patients on adherence to the full course of therapy.
- Be vigilant for signs of hypersensitivity reactions, especially in patients with a history of penicillin allergy.
- Consider potential for Clostridium difficile-associated diarrhea with antibiotic use.
Patient Guidelines
- Complete the entire course of antibiotics, even if symptoms improve.
- Shake the suspension well before each use.
- Report any severe or persistent side effects to your doctor.
- Do not share this medicine with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Amoxicillin generally does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid driving.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain good hygiene to prevent further spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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