Remamox
Generic Name
Amoxicillin
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remamox 250 mg capsule | ৳ 2.50 | N/A |
Description
Overview of the medicine
Remamox 250 mg Capsule contains Amoxicillin, a penicillin-type antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Standard adult dose: 250-500 mg every 8 hours, or 500-875 mg every 12 hours, depending on the severity and type of infection. For severe infections, up to 1g three times daily.
Elderly
No specific dose adjustment for elderly patients with normal renal function. Dose adjustments may be necessary based on renal impairment.
Renal_impairment
Dosage reduction is required for patients with severe renal impairment (creatinine clearance < 30 mL/min). Consult a physician for specific dosing.
How to Take
Take the capsule orally with or without food. Swallow whole with a glass of water. Do not crush or chew. Complete the full course of medication even if symptoms improve.
Mechanism of Action
Amoxicillin is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It prevents the cross-linking of peptidoglycan polymers, which are crucial components of the bacterial cell wall, leading to cell lysis and death.
Pharmacokinetics
Onset
Antibacterial effect typically observed within 1-2 hours after administration.
Excretion
Primarily excreted unchanged in the urine by tubular secretion and glomerular filtration. Approximately 60% of an oral dose is excreted unchanged in the urine within 6-8 hours.
Half life
Approximately 1 to 1.5 hours in adults with normal renal function. This is prolonged in patients with impaired renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 70-90%. Peak plasma concentrations are achieved in about 1-2 hours.
Metabolism
Partially metabolized; about 10-25% of the dose is metabolized to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to penicillin antibiotics (e.g., amoxicillin, penicillin G, ampicillin)
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins, carbapenems)
Drug Interactions
Allopurinol
Concurrent use may increase the incidence of skin rashes.
Methotrexate
Amoxicillin can reduce the renal excretion of methotrexate, potentially increasing its toxicity. Monitor methotrexate levels.
Oral contraceptives
May reduce the effectiveness of oral contraceptives. Advise using additional birth control methods.
Warfarin and other oral anticoagulants
Increased risk of bleeding due to interference with vitamin K metabolism. Close monitoring of INR is recommended.
Tetracyclines, Macrolides, Chloramphenicol
These bacteriostatic drugs may interfere with the bactericidal effect of amoxicillin.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms like nausea, vomiting, and diarrhea may occur. Renal impairment may lead to amoxicillin crystalluria. Treatment is primarily symptomatic and supportive. Gastric lavage may be considered soon after ingestion. Hemodialysis can be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Amoxicillin is excreted in breast milk; use with caution during lactation, as it may lead to sensitization or diarrhea in the infant.
Side Effects
Contraindications
- Known hypersensitivity to penicillin antibiotics (e.g., amoxicillin, penicillin G, ampicillin)
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins, carbapenems)
Drug Interactions
Allopurinol
Concurrent use may increase the incidence of skin rashes.
Methotrexate
Amoxicillin can reduce the renal excretion of methotrexate, potentially increasing its toxicity. Monitor methotrexate levels.
Oral contraceptives
May reduce the effectiveness of oral contraceptives. Advise using additional birth control methods.
Warfarin and other oral anticoagulants
Increased risk of bleeding due to interference with vitamin K metabolism. Close monitoring of INR is recommended.
Tetracyclines, Macrolides, Chloramphenicol
These bacteriostatic drugs may interfere with the bactericidal effect of amoxicillin.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastrointestinal symptoms like nausea, vomiting, and diarrhea may occur. Renal impairment may lead to amoxicillin crystalluria. Treatment is primarily symptomatic and supportive. Gastric lavage may be considered soon after ingestion. Hemodialysis can be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Amoxicillin is excreted in breast milk; use with caution during lactation, as it may lead to sensitization or diarrhea in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Amoxicillin has undergone extensive clinical trials over decades to establish its efficacy and safety in various bacterial infections. Ongoing research continues to explore its resistance patterns and new therapeutic uses.
Lab Monitoring
- Complete Blood Count (CBC) and liver/renal function tests may be advisable during prolonged therapy.
- In cases of suspected Clostridium difficile-associated diarrhea, stool testing for C. difficile toxin.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance and ensure complete eradication of the infection.
- Counsel patients on potential allergic reactions, advising them to seek immediate medical attention for symptoms like rash, itching, swelling, or difficulty breathing.
- Advise patients about the possibility of gastrointestinal upset and recommend taking the medication with food if needed.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor. Do not stop taking it prematurely, even if you feel better.
- Inform your doctor about any history of allergies, especially to penicillin or other antibiotics.
- Report any severe or persistent side effects, particularly rash, severe diarrhea, or difficulty breathing, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Remamox is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or allergic reactions, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids, especially if experiencing diarrhea.
- Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.
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