Remamox
Generic Name
Amoxicillin 500 mg Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remamox 500 mg capsule | ৳ 5.50 | N/A |
Description
Overview of the medicine
Remamox 500 mg Capsule is an antibiotic used to treat a wide range of bacterial infections. It belongs to the penicillin group of antibiotics and works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours, or 500-875 mg every 12 hours, depending on the severity and type of infection. Max 4g/day.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function. Otherwise, similar to adult dose.
Renal_impairment
Dosage reduction required. e.g., CrCl 10-30 mL/min: 250-500 mg every 12 hours. CrCl < 10 mL/min: 250-500 mg every 24 hours.
How to Take
Administer orally with or without food. Can be taken with food to reduce potential gastrointestinal upset. Swallow the capsule whole with water.
Mechanism of Action
Amoxicillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Approximately 30 minutes to 1 hour (antibacterial effect)
Excretion
Primarily renal, via tubular secretion and glomerular filtration. Approximately 60-80% excreted unchanged in urine within 6 hours.
Half life
1 to 1.5 hours in adults with normal renal function
Absorption
Rapidly and well absorbed from the gastrointestinal tract, achieving peak plasma concentrations in 1-2 hours. Bioavailability is approximately 70-90%.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to amoxicillin, other penicillins, or any component of the formulation
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., cephalosporins, carbapenems)
Drug Interactions
Warfarin
May prolong prothrombin time (INR) due to altered gut flora, requiring monitoring.
Probenecid
Increases amoxicillin levels and prolongs its half-life by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely significant, but advise backup method).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, diarrhea, and electrolyte imbalance. In severe cases, renal impairment or convulsions may occur. Treatment is supportive; hemodialysis can remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy when clearly needed. Small amounts are excreted in breast milk; generally considered safe during lactation but monitor for diarrhea or candidiasis in infants.
Side Effects
Contraindications
- Hypersensitivity to amoxicillin, other penicillins, or any component of the formulation
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., cephalosporins, carbapenems)
Drug Interactions
Warfarin
May prolong prothrombin time (INR) due to altered gut flora, requiring monitoring.
Probenecid
Increases amoxicillin levels and prolongs its half-life by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely significant, but advise backup method).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, diarrhea, and electrolyte imbalance. In severe cases, renal impairment or convulsions may occur. Treatment is supportive; hemodialysis can remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy when clearly needed. Small amounts are excreted in breast milk; generally considered safe during lactation but monitor for diarrhea or candidiasis in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Amoxicillin has been extensively studied and is a well-established antibiotic. Many clinical trials support its efficacy and safety across various infections.
Lab Monitoring
- Renal function (in prolonged therapy or renal impairment)
- Liver function tests (rarely, if concerns arise)
- Complete blood count (in prolonged therapy)
Doctor Notes
- Always inquire about penicillin allergy before prescribing.
- Consider renal function for dose adjustments.
- Educate patients on the importance of completing the full course.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Do not share this medicine with others.
- Inform your doctor about any new or worsening symptoms.
- Take with a full glass of water.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Amoxicillin generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during antibiotic treatment.
- Consume probiotics (e.g., yogurt) to help prevent antibiotic-associated diarrhea.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Remamox Brand
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