Renafor-B
Generic Name
Budesonide
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renafor b 400 mcg inhalation capsule | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Renafor-B 400 mcg Inhalation Capsule contains Budesonide, a corticosteroid used to reduce inflammation in the airways, preventing and controlling symptoms of asthma and COPD. It is designed for inhalation using a suitable device.
Uses & Indications
Dosage
Adults
For asthma/COPD, typically 200-400 mcg twice daily, adjusted based on patient response. Max 800 mcg twice daily.
Elderly
No specific dose adjustment generally required, but caution is advised.
Renal_impairment
No dose adjustment necessary.
How to Take
For oral inhalation only using a dry powder inhaler device. Do not swallow the capsule. Ensure proper inhaler technique.
Mechanism of Action
Budesonide is a potent glucocorticoid that exerts anti-inflammatory effects by inhibiting the release of inflammatory mediators and suppressing the migration of inflammatory cells to the airways. It acts locally in the lungs to reduce swelling and mucus production.
Pharmacokinetics
Onset
Therapeutic effects typically observed within 24 hours, but maximum benefit may take 1-2 weeks.
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 2-3 hours.
Absorption
Rapidly absorbed from the lung; systemic bioavailability is low due to extensive first-pass metabolism in the liver.
Metabolism
Extensively metabolized in the liver by CYP3A4 to inactive metabolites.
Side Effects
Contraindications
- Acute bronchospasm (not for acute relief)
- Hypersensitivity to Budesonide or any component of the formulation.
Drug Interactions
Other Corticosteroids
Increased risk of systemic effects if used concurrently.
Ketoconazole, Itraconazole, Ritonavir
May increase systemic exposure to Budesonide due to CYP3A4 inhibition.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause severe problems. Chronic overdose may lead to systemic corticosteroid effects like Cushing's syndrome and adrenal suppression. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Budesonide is excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Acute bronchospasm (not for acute relief)
- Hypersensitivity to Budesonide or any component of the formulation.
Drug Interactions
Other Corticosteroids
Increased risk of systemic effects if used concurrently.
Ketoconazole, Itraconazole, Ritonavir
May increase systemic exposure to Budesonide due to CYP3A4 inhibition.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause severe problems. Chronic overdose may lead to systemic corticosteroid effects like Cushing's syndrome and adrenal suppression. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Budesonide is excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of inhaled Budesonide for asthma and COPD.
Lab Monitoring
- Monitor growth in children and adolescents
- Monitor for signs of adrenal suppression with prolonged high-dose use.
Doctor Notes
- Emphasize correct inhaler technique.
- Advise patients to rinse mouth after each use.
- Not for acute exacerbations.
Patient Guidelines
- Rinse mouth with water after each dose to reduce the risk of oral thrush.
- Do not stop treatment abruptly without consulting a doctor.
- This medicine is for preventive treatment, not for acute asthma attacks.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Unlikely to affect ability to drive or operate machinery.
Lifestyle Advice
- Avoid smoking.
- Maintain good oral hygiene.
- Stay hydrated.
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Global Brand Names
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