Medicine Information

Renafor-B

Name: Renafor-B
Brand: Renafor-B

Inhaler80 mcgAnti-asthmatic & COPD PreparationsATC: R03BA02

Generic Name

Budesonide

Manufacturer

General Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
renafor b 80 mcg inhaler	৳ 625.00	N/A

Description

Overview of the medicine

Renafor-B 80 mcg Inhaler contains Budesonide, an inhaled corticosteroid used for the regular maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It works by reducing inflammation in the airways.

Uses & Indications

Maintenance treatment of asthma in adults and children (6 years and older).

Maintenance treatment of chronic obstructive pulmonary disease (COPD).

Dosage

Adults

Asthma: Initially 1-2 inhalations (80-160 mcg) twice daily. Max 8 inhalations (640 mcg) twice daily. COPD: 2 inhalations (160 mcg) twice daily.

Elderly

No specific dose adjustment is required; refer to adult dosage.

Renal_impairment

No dose adjustment is generally required.

How to Take

For oral inhalation only. Shake the inhaler well before use. Inhale slowly and deeply through the mouth, pressing down on the canister while inhaling. Hold breath for 5-10 seconds, then exhale slowly. Rinse mouth with water and spit out after each use to minimize the risk of oral candidiasis.

Mechanism of Action

Budesonide is a glucocorticosteroid with potent anti-inflammatory activity. It reduces inflammation in the airways, decreases bronchial hyperresponsiveness, and inhibits the release of inflammatory mediators, thereby improving lung function and reducing asthma and COPD symptoms.

Pharmacokinetics

Onset

Initial clinical improvement may be seen within 24 hours, but maximum benefit usually takes 1-2 weeks of regular use.

Excretion

Excreted primarily via the kidneys (approximately 60%) and feces (approximately 40%) as metabolites.

Half life

Approximately 2-3 hours.

Absorption

Rapidly absorbed from the lung; systemic bioavailability is approximately 10-20% due to extensive first-pass metabolism.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to Budesonide or any component of the inhaler.
Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.

Drug Interactions

CYP3A4 Inhibitors

Concurrent administration of strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, itraconazole, clarithromycin) may increase systemic exposure to budesonide.

Storage

Store below 30°C. Protect from direct sunlight, heat, and freezing. Keep out of reach of children.

Overdose

Acute overdose is unlikely with inhaled budesonide due to its low systemic bioavailability. Chronic excessive use may lead to signs and symptoms of hypercorticism. Treatment is supportive and symptomatic.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Budesonide is excreted in human milk; use with caution in nursing mothers.

Side Effects

Contraindications

Known hypersensitivity to Budesonide or any component of the inhaler.
Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required.

Drug Interactions

CYP3A4 Inhibitors

Concurrent administration of strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, itraconazole, clarithromycin) may increase systemic exposure to budesonide.

Storage

Store below 30°C. Protect from direct sunlight, heat, and freezing. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 inhaler (200 actuations)

Shelf Life

24-36 months from manufacturing date (check product for exact date)

Availability

Pharmacies, Hospitals

Approval Status

DGDA Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Budesonide has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in the management of asthma and COPD.

Lab Monitoring

Regular monitoring of growth in children.
Consider monitoring adrenal function in patients on high doses for prolonged periods.

Doctor Notes

Emphasize proper inhaler technique to maximize drug delivery to the lungs and minimize systemic absorption and local side effects.
Educate patients that this is a controller medication and not for acute relief.
Monitor patients, especially children, for potential growth suppression and other systemic corticosteroid effects with prolonged use.

Patient Guidelines

Use the inhaler regularly as prescribed, even when feeling well, for effective control of asthma/COPD.
Rinse your mouth with water and spit it out after each dose to prevent oral thrush.
This inhaler is a preventer, not a reliever. Do not use it for sudden breathing difficulties.
Learn and practice proper inhaler technique to ensure the medication reaches your lungs effectively.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.