Respidox
Generic Name
Doxofylline
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| respidox 100 mg syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Doxofylline is a novel xanthine derivative used to treat bronchial asthma and chronic obstructive pulmonary disease (COPD). It has bronchodilator activity and a better safety profile than traditional xanthines.
Uses & Indications
Dosage
Adults
400 mg twice daily (i.e., 20 ml of 100 mg/5 ml syrup twice daily).
Elderly
Reduced dosage or careful titration, 200 mg twice daily (i.e., 10 ml of 100 mg/5 ml syrup twice daily).
Renal_impairment
Dosage adjustment may be necessary. Administer with caution and monitor renal function.
How to Take
Oral, with or without food. Use the provided measuring cup for accurate dosing.
Mechanism of Action
Doxofylline acts as a bronchodilator primarily through adenosine receptor antagonism and phosphodiesterase inhibition. It helps to relax smooth muscles in the airways, making breathing easier.
Pharmacokinetics
Onset
30-60 minutes.
Excretion
Primarily through urine as metabolites.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed after oral administration.
Metabolism
Extensively metabolized in the liver (CYP450 system).
Side Effects
Contraindications
- •Hypersensitivity to Doxofylline or other xanthine derivatives.
- •Acute myocardial infarction.
- •Hypotension.
- •Severe hepatic impairment.
Drug Interactions
Cimetidine, Erythromycin
May increase Doxofylline plasma levels, leading to increased risk of toxicity.
Phenobarbital, Phenytoin
May decrease Doxofylline plasma levels, reducing its efficacy.
Fluoroquinolones (e.g., Ciprofloxacin)
May increase Doxofylline toxicity due to inhibition of metabolism.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Nausea, vomiting, epigastric pain, headache, irritability, tachycardia, arrhythmias, seizures. Management: Symptomatic and supportive treatment. Gastric lavage, activated charcoal may be considered. Monitor vital signs and manage arrhythmias/seizures if they occur.
Pregnancy & Lactation
Pregnancy: Category B. Use only if clearly needed and the benefits outweigh the potential risks. Lactation: Doxofylline is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
