Reumafen
Generic Name
Diclofenac Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumafen 100 mg suspension | ৳ 33.82 | N/A |
Description
Overview of the medicine
Reumafen 100 mg suspension is an oral non-steroidal anti-inflammatory drug (NSAID) containing Diclofenac Sodium. It is used for the relief of pain, inflammation, and fever associated with various conditions like arthritis, muscle pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
50-150 mg daily in divided doses. For suspension, it's typically 50 mg (2.5 mL) to 100 mg (5 mL) twice daily or as directed by physician.
Elderly
Start with lower doses and monitor for adverse effects. Max 100 mg daily.
Renal_impairment
Use with caution, reduced dosage may be required. Avoid in severe renal impairment.
How to Take
Oral administration. Take with or after food to minimize gastrointestinal upset. Shake the suspension well before use.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins mediate inflammation, pain, and fever, so by inhibiting their production, diclofenac reduces these symptoms.
Pharmacokinetics
Onset
Pain relief usually within 30 minutes to 1 hour.
Excretion
Excreted through urine (approx. 60%) and bile (approx. 35%).
Half life
Approximately 1-2 hours (plasma elimination half-life).
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver by hydroxylation and glucuronidation, mainly by CYP2C9 and CYP2C8.
Side Effects
Contraindications
- Known hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal failure
- Severe heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration.
Diuretics/ACE inhibitors
Reduced antihypertensive effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in 3rd trimester). Avoid in the third trimester due to potential fetal cardiovascular effects. Use with caution during lactation; diclofenac is excreted in breast milk in small amounts. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal failure
- Severe heart failure
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration.
Diuretics/ACE inhibitors
Reduced antihypertensive effect.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (D in 3rd trimester). Avoid in the third trimester due to potential fetal cardiovascular effects. Use with caution during lactation; diclofenac is excreted in breast milk in small amounts. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when stored properly (refer to specific product label).
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of diclofenac for its approved indications. Ongoing research may explore new formulations or indications.
Lab Monitoring
- Liver function tests (LFTs)
- Kidney function tests (KFTs)
- Complete Blood Count (CBC)
- Blood pressure monitoring
Doctor Notes
- Monitor patients for signs of GI bleeding and cardiovascular events, especially with long-term use.
- Assess renal and hepatic function periodically.
- Educate patients on potential side effects and when to seek medical attention.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, stomach pain, or dark stools immediately.
- Avoid concurrent use with other NSAIDs.
- Inform your doctor if you have heart disease, kidney disease, liver disease, or asthma.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Diclofenac may cause dizziness or visual disturbances. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption.
- Maintain a healthy diet.
- Stay hydrated.
- Regular exercise (if physical condition allows).
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