reumafen
Generic Name
Ibuprofen
Manufacturer
Hypothetical Pharmaceuticals Ltd.
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumafen 400 mg tablet | ৳ 1.43 | ৳ 14.30 |
Description
Overview of the medicine
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and anti-inflammatory effects.
Uses & Indications
Dosage
Adults
200-400 mg every 4-6 hours as needed. Max 1200 mg/day for OTC use, up to 3200 mg/day under medical supervision.
Elderly
Similar to adults, but cautious use and lower doses might be considered due to increased risk of side effects.
Renal_impairment
Use with caution, dose reduction may be necessary. Avoid in severe renal impairment.
How to Take
Orally, preferably with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.
Pharmacokinetics
Onset
30-60 minutes for analgesia.
Excretion
Mainly in the urine (around 90-95%) as metabolites or their conjugates; small amount in feces.
Half life
Approximately 1.8-2.5 hours.
Absorption
Rapidly absorbed from the GI tract. Peak plasma concentrations usually within 1-2 hours.
Metabolism
Primarily in the liver by oxidation and conjugation to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal, hepatic, or heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids
Increased risk of GI ulceration and bleeding.
Lithium, Methotrexate
Increased plasma levels of these drugs.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, lethargy, dizziness, ringing in ears. Treatment is supportive and symptomatic; gastric lavage/activated charcoal within an hour of ingestion may be considered.
Pregnancy & Lactation
Avoid during the third trimester due to risk to the fetus. Use with caution in first and second trimesters if benefits outweigh risks. Small amounts excreted in breast milk; generally considered safe for short-term use during lactation, but consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal, hepatic, or heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids
Increased risk of GI ulceration and bleeding.
Lithium, Methotrexate
Increased plasma levels of these drugs.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, lethargy, dizziness, ringing in ears. Treatment is supportive and symptomatic; gastric lavage/activated charcoal within an hour of ingestion may be considered.
Pregnancy & Lactation
Avoid during the third trimester due to risk to the fetus. Use with caution in first and second trimesters if benefits outweigh risks. Small amounts excreted in breast milk; generally considered safe for short-term use during lactation, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, supermarkets
Approval Status
Approved by major regulatory bodies globally
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of ibuprofen for its approved indications.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function (ALT, AST)
- Complete blood count (CBC) if long-term use
Doctor Notes
- Consider patient's cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term use.
- Start with the lowest effective dose for the shortest possible duration to minimize risks.
- Monitor renal function, liver function, and blood pressure in patients on long-term therapy.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the recommended dose.
- Report any unusual bleeding, severe stomach pain, or allergic reactions to your doctor.
- Avoid concomitant use with other NSAIDs.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for your next scheduled dose. Do not double dose.
Driving Precautions
May cause dizziness or drowsiness; advise caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol while taking this medicine as it can increase the risk of stomach problems.
- Maintain adequate hydration.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in reumafen Brand
Other medicines available under the same brand name
