Rislock
Generic Name
Risperidone
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rislock 1 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Rislock 1 mg tablet is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar mania, and irritability associated with autistic disorder in children and adolescents.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 0.5-1 mg twice daily, gradually increase to a target range of 2-8 mg/day. Bipolar mania: Initially 2-3 mg once daily, adjusted as needed.
Elderly
Lower initial doses (e.g., 0.25-0.5 mg twice daily) and slower titration recommended due to increased sensitivity and potential for adverse effects.
Renal_impairment
Initial dose 0.25-0.5 mg twice daily, with slower titration. Max dose typically 1.5 mg twice daily.
How to Take
Rislock tablets can be taken orally with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Risperidone selectively blocks dopamine D2 and serotonin 5-HT2A receptors in the brain, thereby improving symptoms of psychosis and mood disturbances. It also has affinity for alpha1-adrenergic and H1 histaminergic receptors.
Pharmacokinetics
Onset
Clinical effects may be observed within a few days, but full therapeutic benefits may take several weeks.
Excretion
Approximately 70% excreted in urine and 14% in feces, mainly as metabolites.
Half life
Risperidone has a half-life of about 3 hours; its active metabolite, 9-hydroxyrisperidone, has a half-life of about 20-24 hours.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 1-2 hours for risperidone and 3-4 hours for its active metabolite, 9-hydroxyrisperidone.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 to its active metabolite, 9-hydroxyrisperidone. Also undergoes N-dealkylation.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or any component of the formulation
Drug Interactions
Antihypertensive agents
May increase the risk of orthostatic hypotension.
Levodopa and dopamine agonists
May antagonize the effects of levodopa and other dopamine agonists.
CNS depressants (e.g., alcohol, benzodiazepines)
May potentiate the sedative effects of risperidone.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. There is no specific antidote; treatment should be supportive and symptomatic, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted in human milk, therefore, breastfeeding should be avoided during treatment.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or any component of the formulation
Drug Interactions
Antihypertensive agents
May increase the risk of orthostatic hypotension.
Levodopa and dopamine agonists
May antagonize the effects of levodopa and other dopamine agonists.
CNS depressants (e.g., alcohol, benzodiazepines)
May potentiate the sedative effects of risperidone.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. There is no specific antidote; treatment should be supportive and symptomatic, including gastric lavage and activated charcoal if appropriate.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted in human milk, therefore, breastfeeding should be avoided during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Risperidone's efficacy and safety have been established through numerous clinical trials spanning various indications, including extensive studies in schizophrenia, bipolar disorder, and autism-related irritability.
Lab Monitoring
- Baseline and periodic monitoring of weight, blood glucose, and lipid profile.
- Prolactin levels should be monitored, especially if symptomatic hyperprolactinemia occurs.
- ECG monitoring for QT prolongation, especially in patients with pre-existing cardiac conditions.
Doctor Notes
- Monitor patients regularly for adverse effects, especially metabolic changes and extrapyramidal symptoms.
- Emphasize patient adherence to treatment and avoid abrupt discontinuation.
- Careful dose titration is necessary, especially in elderly or renally impaired patients.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not stop taking Rislock suddenly without consulting your doctor.
- Avoid alcohol and other CNS depressants while on this medication.
- Report any unusual side effects or changes in mood/behavior to your doctor immediately.
- Attend regular follow-up appointments.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rislock may cause drowsiness, dizziness, or visual disturbances. Do not drive or operate heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity to help manage weight gain.
- Stay hydrated and avoid overheating, especially in hot weather.
- Practice good sleep hygiene.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Rislock Brand
Other medicines available under the same brand name
