Rislock
Generic Name
Risperidone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rislock 2 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Rislock 2 mg Tablet contains Risperidone, an atypical antipsychotic medication used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 2 mg once daily, target dose 4-6 mg/day. Bipolar mania: Initial 2-3 mg once daily, target dose 1-6 mg/day. Doses greater than 16 mg/day have not been shown to be more effective.
Elderly
A starting dose of 0.5 mg twice daily is recommended, with gradual titration to an effective dose. Close monitoring is advised.
Renal_impairment
Initial dose of 0.5 mg twice daily, with careful titration. Doses should be titrated slowly, and the maximum dose should not exceed 4 mg/day.
How to Take
Rislock tablet can be taken orally, with or without food. It should be swallowed whole with water.
Mechanism of Action
Risperidone is a selective monoaminergic antagonist with high affinity for serotonin 5-HT2 and dopamine D2 receptors. It also binds to alpha1-adrenergic and, with lower affinity, to H1-histaminergic and alpha2-adrenergic receptors. It acts as an antagonist at these receptors, helping to normalize neurotransmitter activity in the brain.
Pharmacokinetics
Onset
Initial therapeutic effects can be observed within a few days to a week, but full therapeutic response may take several weeks.
Excretion
Approximately 70% excreted in urine (35-45% as 9-hydroxyrisperidone, 10-20% as risperidone), and 14% in feces, within one week of administration.
Half life
Risperidone: approximately 3 hours. 9-hydroxyrisperidone: approximately 20-24 hours.
Absorption
Well absorbed after oral administration, peak plasma concentration achieved within 1-2 hours for risperidone and 3-6 hours for 9-hydroxyrisperidone (active metabolite). Bioavailability is approximately 70%.
Metabolism
Extensive hepatic metabolism primarily via CYP2D6 to 9-hydroxyrisperidone (paliperidone), which is equipotent to risperidone. A minor pathway involves N-dealkylation.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any excipient of the tablet.
Drug Interactions
Antihypertensives
May enhance the hypotensive effects.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased sedative effects; use with caution.
CYP2D6 inhibitors (e.g., Fluoxetine, Paroxetine, Quinidine)
May increase plasma concentrations of risperidone and its active metabolite.
CYP3A4 inducers (e.g., Carbamazepine, Rifampicin, Phenytoin)
May decrease plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. In severe cases, QT prolongation and convulsions may occur. Management is supportive, involving maintaining an adequate airway, oxygenation, and ventilation. Cardiovascular monitoring should be initiated immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Neonates exposed to antipsychotic drugs during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Risperidone is excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any excipient of the tablet.
Drug Interactions
Antihypertensives
May enhance the hypotensive effects.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased sedative effects; use with caution.
CYP2D6 inhibitors (e.g., Fluoxetine, Paroxetine, Quinidine)
May increase plasma concentrations of risperidone and its active metabolite.
CYP3A4 inducers (e.g., Carbamazepine, Rifampicin, Phenytoin)
May decrease plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. In severe cases, QT prolongation and convulsions may occur. Management is supportive, involving maintaining an adequate airway, oxygenation, and ventilation. Cardiovascular monitoring should be initiated immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Neonates exposed to antipsychotic drugs during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Risperidone is excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specific details on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Risperidone has been extensively studied in numerous clinical trials to establish its efficacy and safety for its approved indications across various populations, including adults, adolescents, and children.
Lab Monitoring
- Baseline and periodic monitoring of blood glucose and lipid profile (due to risk of metabolic changes).
- Prolactin levels (especially if symptoms of hyperprolactinemia occur).
- Complete Blood Count (CBC) with differential (occasionally for agranulocytosis risk, though rare).
Doctor Notes
- Emphasize the importance of patient compliance and not discontinuing the medication abruptly.
- Monitor for metabolic side effects (weight, glucose, lipids) and extrapyramidal symptoms regularly.
- Assess prolactin levels if symptoms of hyperprolactinemia emerge.
- Caution against use in elderly patients with dementia-related psychosis due to increased mortality risk.
Patient Guidelines
- Take Rislock exactly as prescribed by your doctor. Do not change your dose or stop taking it without consulting your doctor.
- Avoid consuming alcohol while on this medication, as it may enhance drowsiness and dizziness.
- Report any unusual or severe side effects to your doctor immediately.
- Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause drowsiness or dizziness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Rislock may cause drowsiness, dizziness, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that risperidone therapy does not affect them adversely.
Lifestyle Advice
- Engage in regular physical activity and maintain a balanced diet to help manage potential weight gain.
- Avoid sudden changes in posture to minimize the risk of orthostatic hypotension (dizziness upon standing).
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