Rislock
Generic Name
Risperidone
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rislock 4 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Rislock 4 mg Tablet contains Risperidone, an atypical antipsychotic medication used to treat schizophrenia, bipolar disorder (manic or mixed episodes), and irritability associated with autistic disorder in children and adolescents.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 2 mg once daily, target dose 4-6 mg/day, maximum 16 mg/day. Bipolar mania: Initially 2-3 mg once daily, target dose 1-6 mg/day. Autism: Individualized, often starting at 0.5 mg/day.
Elderly
Lower starting doses (e.g., 0.5 mg twice daily) and slower titration are recommended due to increased sensitivity and potential for adverse effects.
Renal_impairment
Initial dose 0.5 mg twice daily, increase slowly. Use with caution. Maximum 8 mg/day.
How to Take
Rislock tablet should be taken orally, with or without food. It should be swallowed whole with a glass of water.
Mechanism of Action
Risperidone is thought to work by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain, which helps to improve mood, thinking, and behavior.
Pharmacokinetics
Onset
Therapeutic effects may begin within a few days, but full benefits may take several weeks.
Excretion
Approximately 70% excreted in urine and 14% in feces, mainly as the active fraction.
Half life
Risperidone: approximately 3 hours. 9-hydroxyrisperidone: approximately 21 hours.
Absorption
Well absorbed after oral administration. Peak plasma concentrations of risperidone occur within 1 hour; for 9-hydroxyrisperidone (active metabolite), within 3-4 hours.
Metabolism
Extensively metabolized in the liver by CYP2D6 to 9-hydroxyrisperidone, which is an active metabolite with similar pharmacological activity to risperidone.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any of the excipients.
- Patients with severe CNS depression.
Drug Interactions
Antihypertensive agents
May enhance hypotensive effects.
CNS Depressants (e.g., alcohol, benzodiazepines)
May have additive sedative effects.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine)
May increase risperidone plasma levels.
CYP3A4 Inducers (e.g., carbamazepine, rifampicin)
May decrease risperidone plasma levels and its active metabolite.
Storage
Store below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, including airway maintenance, oxygenation, and hydration. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Risperidone is excreted in breast milk; advise against breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any of the excipients.
- Patients with severe CNS depression.
Drug Interactions
Antihypertensive agents
May enhance hypotensive effects.
CNS Depressants (e.g., alcohol, benzodiazepines)
May have additive sedative effects.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine)
May increase risperidone plasma levels.
CYP3A4 Inducers (e.g., carbamazepine, rifampicin)
May decrease risperidone plasma levels and its active metabolite.
Storage
Store below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, including airway maintenance, oxygenation, and hydration. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Risperidone is excreted in breast milk; advise against breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved (Generic available)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Risperidone has undergone numerous clinical trials demonstrating its efficacy and safety in various psychiatric conditions. Ongoing research continues to explore its applications and long-term effects.
Lab Monitoring
- Monitor blood glucose and lipid profile periodically.
- Monitor weight regularly.
- Monitor prolactin levels if clinically indicated.
- Blood pressure monitoring, especially for orthostatic hypotension.
Doctor Notes
- Monitor patients closely for Neuroleptic Malignant Syndrome (NMS) and Tardive Dyskinesia (TD).
- Regularly assess metabolic parameters (weight, glucose, lipids) due to increased risk of metabolic syndrome.
- Educate patients and caregivers on medication adherence and potential side effects.
- Use caution in patients with known cardiovascular disease, cerebrovascular disease, or conditions predisposing to hypotension.
Patient Guidelines
- Do not stop taking Rislock abruptly without consulting your doctor.
- Avoid alcohol consumption while on this medication.
- Report any unusual muscle movements (especially in face or tongue) or high fever, stiffness, confusion to your doctor immediately.
- Stay hydrated to prevent dehydration.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Rislock may cause drowsiness, dizziness, or blurred vision. Patients should be cautious when driving or operating machinery until they know how this medication affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet to manage weight.
- Engage in regular physical activity.
- Avoid smoking.
- Practice stress management techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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