Rocipro
Generic Name
rocipro-750-mg-tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rocipro 750 mg tablet | ৳ 18.00 | ৳ 144.00 |
Description
Overview of the medicine
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections, including those affecting the urinary tract, respiratory system, skin, and bones.
Uses & Indications
Dosage
Adults
For severe or complicated infections, 750 mg orally every 12 hours for 7-14 days. Dosage and duration depend on the type and severity of infection. For uncomplicated urinary tract infections, 250-500 mg every 12 hours.
Elderly
Dosage should be adjusted based on renal function. Generally, the lower end of the adult dose range is recommended.
Renal_impairment
For creatinine clearance 30-60 mL/min, 750 mg every 24 hours. For creatinine clearance < 30 mL/min, 500 mg every 24 hours or 250-500 mg every 18-24 hours depending on the severity.
How to Take
Take the tablet orally with a glass of water, with or without food. Do not chew or crush. Avoid taking with milk, yogurt, or calcium-fortified juices, and separate from antacids or iron/zinc supplements by at least 2 hours before or 6 hours after.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
0.5-2 hours (time to peak plasma concentration).
Excretion
Primarily excreted unchanged in urine (50-70%) and feces (15%). Renal excretion involves both glomerular filtration and tubular secretion.
Half life
Approximately 3-5 hours in adults with normal renal function.
Absorption
Rapidly absorbed after oral administration with a bioavailability of 70-80%. Peak plasma concentrations are reached within 0.5-2 hours.
Metabolism
Partially metabolized in the liver to four active metabolites (desethyleneciprofloxacin, sulfociprofloxacin, oxociprofloxacin, and formylciprofloxacin), which possess some antimicrobial activity but are less potent than the parent compound.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolone antibiotics
- Concomitant administration with tizanidine
- History of tendinopathy associated with quinolone use
Drug Interactions
Tizanidine
Concomitant use significantly increases tizanidine plasma concentrations, leading to increased risk of hypotension and sedation. Concomitant use is contraindicated.
Theophylline
Ciprofloxacin can increase serum concentrations of theophylline, leading to increased risk of theophylline toxicity. Monitor theophylline levels and adjust dose as needed.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Warfarin and other oral anticoagulants
Enhanced anticoagulant effect, increased risk of bleeding. Monitor INR closely.
Antacids containing magnesium or aluminum, sucralfate, didanosine (chewable/buffered tablets or pediatric powder), iron or zinc salts
Reduced oral absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of acute overdose, gastric lavage or induction of emesis may be considered. Activated charcoal may be administered to reduce absorption. Maintain adequate hydration. Symptomatic and supportive treatment should be initiated. Ciprofloxacin is only minimally removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnant women only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. Due to the potential for serious adverse reactions in nursing infants (e.g., cartilage damage), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolone antibiotics
- Concomitant administration with tizanidine
- History of tendinopathy associated with quinolone use
Drug Interactions
Tizanidine
Concomitant use significantly increases tizanidine plasma concentrations, leading to increased risk of hypotension and sedation. Concomitant use is contraindicated.
Theophylline
Ciprofloxacin can increase serum concentrations of theophylline, leading to increased risk of theophylline toxicity. Monitor theophylline levels and adjust dose as needed.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Warfarin and other oral anticoagulants
Enhanced anticoagulant effect, increased risk of bleeding. Monitor INR closely.
Antacids containing magnesium or aluminum, sucralfate, didanosine (chewable/buffered tablets or pediatric powder), iron or zinc salts
Reduced oral absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of acute overdose, gastric lavage or induction of emesis may be considered. Activated charcoal may be administered to reduce absorption. Maintain adequate hydration. Symptomatic and supportive treatment should be initiated. Ciprofloxacin is only minimally removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnant women only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. Due to the potential for serious adverse reactions in nursing infants (e.g., cartilage damage), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for treating a wide range of bacterial infections in various patient populations.
Lab Monitoring
- Renal function tests (creatinine, BUN) for patients with impaired renal function
- Liver function tests (ALT, AST, alkaline phosphatase) during prolonged therapy or in patients with hepatic impairment
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Counsel patients about the black box warnings regarding tendinopathy, tendon rupture, peripheral neuropathy, and CNS effects.
- Emphasize the importance of completing the full course of therapy.
- Advise patients to avoid concurrent administration with dairy products, antacids, and certain supplements.
- Monitor renal function, especially in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Do not take with dairy products or calcium-fortified juices.
- Avoid excessive exposure to direct sunlight or artificial UV light, and use sunscreen.
- Report any pain, swelling, or inflammation in tendons immediately.
- Drink plenty of fluids while taking this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ciprofloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to know how they react to the drug before driving or operating machinery.
Lifestyle Advice
- Maintain good hydration to help prevent crystalluria.
- Avoid alcohol consumption during the treatment period as it may exacerbate some side effects.
- Engage in light physical activity; avoid strenuous exercise that could strain tendons, especially during the first few weeks of treatment.
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