Romycin
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Plc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| romycin 1 eye drop | ৳ 115.00 | N/A |
| romycin 500 mg tablet | ৳ 40.00 | ৳ 400.00 |
| romycin 250 mg capsule | ৳ 20.00 | ৳ 80.00 |
| romycin 200 mg suspension | ৳ 90.00 | N/A |
Description
Overview of the medicine
Romycin (Azithromycin) is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days.
Elderly
No specific dosage adjustment required for elderly patients, but caution for cardiac comorbidities.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment.
How to Take
Take orally, generally once daily. For optimal absorption, it is usually advised to take 1 hour before or 2 hours after meals, though some formulations can be taken with food.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby blocking the translocation of peptides.
Pharmacokinetics
Onset
Clinical effects typically observed within 2-3 hours.
Excretion
Mainly excreted unchanged in bile, with a smaller amount in urine.
Half life
Terminal elimination half-life is 2 to 4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Primarily metabolized in the liver, but only a small amount.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations.
Cyclosporine
Increased cyclosporine levels.
Antacids (containing aluminum or magnesium)
Reduced absorption of azithromycin; take azithromycin at least 2 hours apart.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations.
Cyclosporine
Increased cyclosporine levels.
Antacids (containing aluminum or magnesium)
Reduced absorption of azithromycin; take azithromycin at least 2 hours apart.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage and general symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Azithromycin is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
DGDA approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has undergone extensive clinical trials supporting its efficacy and safety for various bacterial infections. Ongoing research explores its anti-inflammatory and immunomodulatory effects.
Lab Monitoring
- Monitor liver function tests in patients with pre-existing hepatic impairment or during prolonged use.
- ECG monitoring for patients at risk of QT prolongation.
Doctor Notes
- Counsel patients on the importance of completing the full course of therapy.
- Be aware of potential drug interactions, especially with warfarin and other QT-prolonging agents.
- Consider C. difficile-associated diarrhea in patients presenting with diarrhea after antibiotic use.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Do not share this medication with others.
- Report any severe side effects immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Romycin can cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated, especially if experiencing diarrhea.
- Avoid alcohol if it aggravates gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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