Adults

Typically 500 mg to 2 gm intravenously every 8 hours, depending on the type and severity of infection, and the susceptibility of the causative organism.

Elderly

Dose adjustment based on renal function is necessary in elderly patients with impaired kidney function.

Renal_impairment

Dose reduction and/or increased dosing interval are required for patients with creatinine clearance less than 50 mL/min.

Onset

Rapid, typically within minutes of IV administration.

Excretion

Excreted primarily by the kidneys, approximately 70% as unchanged drug within 12 hours.

Half life

Approximately 1 hour in adults with normal renal function.

Absorption

Rapid and complete absorption after intravenous administration.

Metabolism

Undergoes minimal metabolism; primarily hydrolyzed to an open-ring metabolite which is inactive.

Probenecid

Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem.

Valproic Acid

Concurrent use with valproic acid or divalproex sodium can significantly reduce valproic acid concentrations, potentially leading to breakthrough seizures.