Ronem
Generic Name
Meropenem 500 mg injection
Manufacturer
Reputable Pharmaceutical Co. Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ronem 500 mg injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Ronem 500 mg Injection contains Meropenem, a broad-spectrum carbapenem antibiotic used to treat a wide range of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria, including those resistant to other antibiotics. Administered intravenously, it is typically reserved for severe infections in hospital settings.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g IV every 8 hours, depending on the severity and type of infection. For meningitis, 1 g IV every 8 hours.
Elderly
Dosage adjustment may be required based on renal function.
Renal_impairment
Reduced dosage is necessary for patients with creatinine clearance < 50 mL/min.
How to Take
Administered intravenously (IV) over 15 to 30 minutes by infusion or as a 5-minute bolus injection (for doses up to 1 g). Reconstitution with sterile water for injection or compatible intravenous fluids.
Mechanism of Action
Meropenem is a carbapenem antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It has a high affinity for PBPs 2, 3, and 4 of *E. coli* and *P. aeruginosa*.
Pharmacokinetics
Onset
Within minutes after IV administration.
Excretion
Approximately 70% of the administered dose is excreted unchanged in the urine within 12 hours.
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapidly and completely absorbed after intravenous administration.
Metabolism
Minimal hepatic metabolism; primarily metabolized by hydrolysis of the beta-lactam ring to an inactive metabolite.
Side Effects
Contraindications
- •Hypersensitivity to meropenem or other carbapenem antibiotics
- •Severe hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, cephalosporins)
Drug Interactions
Probenecid
Increases the plasma half-life and concentration of meropenem.
Valproic acid
Meropenem can significantly decrease valproic acid levels, leading to loss of seizure control.
Oral anticoagulants (e.g., Warfarin)
Increased anticoagulant effect may occur, requiring INR monitoring.
Storage
Store below 25°C, protected from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to manufacturer's instructions.
Overdose
In case of overdose, meropenem can be removed by hemodialysis. Symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as directed. Reconstituted solution shelf life varies.
Availability
Hospitals, pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for original compound
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
