Ronem
Generic Name
Meropenem
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ronem 250 mg injection | ৳ 400.00 | N/A |
Description
Overview of the medicine
Meropenem is a broad-spectrum carbapenem antibiotic used to treat a wide variety of bacterial infections, including complicated skin and soft tissue infections, intra-abdominal infections, and bacterial meningitis.
Uses & Indications
Dosage
Adults
Usually 500 mg to 1 g IV every 8 hours, depending on the infection. For meningitis, 2 g IV every 8 hours.
Elderly
Dosage adjustment may be needed based on renal function.
Renal_impairment
Significant dose adjustment required; e.g., for CrCl 26-50 mL/min, 1 g every 12 hours; for CrCl 10-25 mL/min, 500 mg every 12 hours.
How to Take
Intravenous (IV) infusion over 15-30 minutes, or IV bolus over 5 minutes (for doses up to 1 g).
Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV administration.
Excretion
Primarily excreted unchanged by the kidneys (approximately 70% as unchanged drug within 12 hours).
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapidly absorbed after intravenous administration. Bioavailability is 100%.
Metabolism
Limited hepatic metabolism; primarily metabolized by hydrolysis of the beta-lactam ring to an inactive metabolite.
Side Effects
Contraindications
- •Known hypersensitivity to meropenem, other carbapenems, or any component of the formulation.
- •Hypersensitivity to beta-lactam antibiotics (e.g., penicillin, cephalosporins) due to potential cross-reactivity.
Drug Interactions
Probenecid
Increases meropenem plasma concentrations and prolongs its half-life by inhibiting renal tubular secretion.
Valproic Acid/Sodium Valproate
May decrease valproic acid serum concentrations, leading to loss of seizure control. Co-administration generally not recommended.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect. Close monitoring of INR is recommended.
Storage
Store below 30°C. Protect from light. Reconstituted solution stable for a limited time (e.g., 2 hours at room temperature, 12-24 hours under refrigeration).
Overdose
In case of overdose, discontinue meropenem and provide supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Use in pregnancy only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened at room temperature.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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