Rupoma
Generic Name
Rupatadine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rupoma 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
| rupoma 5 mg oral solution | ৳ 60.00 | N/A |
Description
Overview of the medicine
Rupatadine is a non-sedating, long-acting, selective H1-receptor antagonist used for the symptomatic treatment of allergic rhinitis and urticaria.
Uses & Indications
Dosage
Adults
Adults and adolescents (12 years and older): 10 mg once daily.
Elderly
No dose adjustment is required in elderly patients, but caution is advised due to potential age-related decrease in renal/hepatic function.
Renal_impairment
Use with caution in patients with renal impairment. No specific dose adjustment guidelines for severe renal impairment.
How to Take
Oral administration, with or without food.
Mechanism of Action
Rupatadine is a second-generation H1-antihistamine with selective peripheral H1-receptor antagonist activity. It also inhibits platelet-activating factor (PAF) and mast cell degranulation.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Eliminated primarily via feces (60.9%) and urine (34.6%).
Half life
Terminal half-life is approximately 5.9 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma levels reached in 0.75-1.5 hours. Low oral bioavailability (approx. 10%) due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, mainly by cytochrome P450 (CYP3A4) into active and inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to rupatadine or any excipients.
- •Patients with known QT prolongation.
Drug Interactions
CNS depressants (e.g., alcohol)
May enhance CNS depressant effects.
Ketoconazole (potent CYP3A4 inhibitor)
Increases rupatadine exposure significantly.
Erythromycin (moderate CYP3A4 inhibitor)
Increases rupatadine exposure.
Storage
Store below 30°C, protected from light and moisture.
Overdose
In case of overdose, seek immediate medical attention. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Avoid during pregnancy and lactation unless potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies in Bangladesh and other countries
Approval Status
Approved
Patent Status
Off-patent in many regions
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Global Brand Names
International brand names for this medicine
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