Saltide
Generic Name
Salbutamol + Ipratropium Bromide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
saltide 100 mcg inhaler | ৳ 250.00 | N/A |
saltide 25 mg respirator solution | ৳ 16.00 | N/A |
Description
Overview of the medicine
Saltide is a combination bronchodilator used to relieve bronchospasm in patients with chronic obstructive pulmonary disease (COPD) and asthma. It combines a fast-acting beta-2 agonist (Salbutamol) with a short-acting anticholinergic (Ipratropium Bromide) to provide synergistic bronchodilation.
Uses & Indications
Dosage
Adults
One 2.5 ml unit-dose vial (Salbutamol 2.5 mg + Ipratropium Bromide 0.5 mg) administered via nebulizer 3 to 4 times daily, as needed.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in patients with prostatic hyperplasia or narrow-angle glaucoma.
Renal_impairment
No dose adjustment is usually necessary due to minimal systemic absorption.
How to Take
Administer by oral inhalation using a suitable nebulizer until the nebulizer chamber is empty. Do not swallow the solution. The full duration of nebulization takes approximately 5-15 minutes.
Mechanism of Action
Salbutamol selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, leading to bronchodilation. Ipratropium Bromide is an anticholinergic agent that blocks muscarinic receptors in the airways, preventing bronchoconstriction and causing bronchodilation. The combination provides an additive effect.
Pharmacokinetics
Onset
Salbutamol: ~5 minutes. Ipratropium Bromide: ~15-30 minutes. Combined: Rapid onset.
Excretion
Both drugs are primarily excreted renally, with a small portion excreted in feces.
Half life
Salbutamol: 4-6 hours. Ipratropium Bromide: ~1.6 hours.
Absorption
Salbutamol is rapidly absorbed after inhalation, with about 10-20% systemic bioavailability. Ipratropium Bromide is poorly absorbed systemically (less than 10%) from the lungs.
Metabolism
Salbutamol is metabolized in the liver via sulfate conjugation. Ipratropium Bromide is minimally metabolized by esterases.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol, Ipratropium Bromide, atropine or its derivatives, or any component of the formulation
- Patients with hypertrophic obstructive cardiomyopathy or tachyarrhythmia
- Acute severe asthma where a rapid response is critical (use single-agent bronchodilator first)
Drug Interactions
Diuretics
May exacerbate hypokalemia induced by salbutamol.
Beta-blockers
Can block the bronchodilatory effect of salbutamol.
MAOIs and TCAs
May potentiate the cardiovascular effects of salbutamol.
Other anticholinergics
May potentiate anticholinergic effects and side effects.
Other sympathomimetics
May increase the risk of cardiovascular adverse effects.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children. Use immediately after opening the protective pouch.
Overdose
Symptoms of overdose may include tachycardia, palpitations, tremor, hypertension, dry mouth, blurred vision, and urinary retention. Treatment is symptomatic and supportive, discontinuing the drug and monitoring vital signs. Electrolyte monitoring, especially potassium, is advised.
Pregnancy & Lactation
Pregnancy Category C (Salbutamol) and B (Ipratropium Bromide). Use only if the potential benefit justifies the potential risk to the fetus. Both are excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Salbutamol, Ipratropium Bromide, atropine or its derivatives, or any component of the formulation
- Patients with hypertrophic obstructive cardiomyopathy or tachyarrhythmia
- Acute severe asthma where a rapid response is critical (use single-agent bronchodilator first)
Drug Interactions
Diuretics
May exacerbate hypokalemia induced by salbutamol.
Beta-blockers
Can block the bronchodilatory effect of salbutamol.
MAOIs and TCAs
May potentiate the cardiovascular effects of salbutamol.
Other anticholinergics
May potentiate anticholinergic effects and side effects.
Other sympathomimetics
May increase the risk of cardiovascular adverse effects.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children. Use immediately after opening the protective pouch.
Overdose
Symptoms of overdose may include tachycardia, palpitations, tremor, hypertension, dry mouth, blurred vision, and urinary retention. Treatment is symptomatic and supportive, discontinuing the drug and monitoring vital signs. Electrolyte monitoring, especially potassium, is advised.
Pregnancy & Lactation
Pregnancy Category C (Salbutamol) and B (Ipratropium Bromide). Use only if the potential benefit justifies the potential risk to the fetus. Both are excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specific to manufacturer's instructions.
Availability
Pharmacies, hospitals
Approval Status
Widely approved globally
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Salbutamol and Ipratropium Bromide combination in managing COPD and asthma symptoms, including studies supporting its use in acute exacerbations.
Lab Monitoring
- Routine lab monitoring is generally not required. Potassium levels may be monitored in patients at risk of hypokalemia, especially with high doses or concomitant use of diuretics.
Doctor Notes
- Emphasize proper patient counseling on correct nebulization technique and adherence.
- Be aware of potential for paradoxical bronchospasm, especially on first use.
- Advise patients with narrow-angle glaucoma or prostatic hyperplasia to use with caution and report any visual changes or urinary difficulties.
- Monitor potassium levels in susceptible patients on high doses or concomitant diuretics.
Patient Guidelines
- Ensure correct nebulization technique to maximize drug delivery to the lungs.
- Do not exceed the prescribed dose or frequency.
- Seek immediate medical attention if breathing difficulties worsen after using the medicine.
- Avoid getting the solution into the eyes, as it may cause temporary blurred vision or precipitate narrow-angle glaucoma.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Saltide may cause dizziness, blurred vision, or tremor. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Smoking cessation is crucial for patients with COPD and asthma. Identify and avoid triggers for bronchospasm, such as allergens, irritants, or cold air. Maintain good hydration.
- Regular exercise as tolerated and a healthy diet can support lung health.
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