Sanfix
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sanfix 200 mg capsule | ৳ 35.11 | ৳ 245.77 |
Description
Overview of the medicine
Sanfix 200 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
200-400 mg once daily or in two divided doses for 7-14 days depending on the infection.
Elderly
Similar to adults, but dose adjustment may be necessary in case of severe renal impairment.
Renal_impairment
Creatinine clearance 21-60 ml/min: 300 mg daily. Creatinine clearance less than 20 ml/min: 200 mg daily.
How to Take
Take orally, with or without food. For best results, take at the same time each day.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapidly absorbed, peak plasma concentrations typically occur within 2-6 hours.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. The remainder is excreted via non-renal mechanisms, possibly biliary.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, food may delay but not significantly reduce absorption.
Metabolism
Minimal hepatic metabolism; no active metabolites have been identified.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporin antibiotics.
- Known hypersensitivity to penicillin antibiotics (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase oral bioavailability of cefixime.
Carbamazepine
Concomitant use may increase cefixime plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding. Close monitoring of coagulation parameters is advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive therapy should be administered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporin antibiotics.
- Known hypersensitivity to penicillin antibiotics (due to potential cross-reactivity).
Drug Interactions
Nifedipine
May increase oral bioavailability of cefixime.
Carbamazepine
Concomitant use may increase cefixime plasma concentrations.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without clinical bleeding. Close monitoring of coagulation parameters is advised.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive therapy should be administered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the manufacturing date, consult package for exact date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials to establish its efficacy and safety in treating a variety of bacterial infections. Ongoing post-marketing surveillance continues to monitor its profile.
Lab Monitoring
- Renal function tests (for patients with pre-existing renal impairment or on prolonged therapy)
- Coagulation parameters (e.g., PT/INR) if co-administered with anticoagulants
- Complete blood count (rarely, for prolonged use)
Doctor Notes
- Prior to initiating therapy, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.
- Adjust dosage in patients with significant renal impairment.
- Counsel patients on the importance of completing the full course of treatment to prevent resistance.
Patient Guidelines
- Complete the full prescribed course of antibiotics, even if symptoms improve.
- Do not save medication for future use or share with others.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, patients should be aware of possible side effects like dizziness.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Follow a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Sanfix Brand
Other medicines available under the same brand name
