Adults

400 mg once daily or 200 mg twice daily. Duration of treatment depends on the infection, typically 7-14 days.

Elderly

No dosage adjustment needed unless severe renal impairment. In such cases, follow renal impairment guidelines.

Renal_impairment

For creatinine clearance (CrCl) 21-60 mL/min, 300 mg daily. For CrCl < 20 mL/min, 200 mg daily.

Onset

Peak plasma concentrations are achieved in 2-6 hours after oral administration.

Excretion

Approximately 50-60% of an absorbed dose is excreted unchanged in the urine over 24 hours. Some is also excreted via bile.

Half life

Average plasma half-life is 3-4 hours, which may be prolonged in renal impairment.

Absorption

Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly alter the extent of absorption.

Metabolism

Not extensively metabolized. A small fraction may be metabolized in the liver.

Warfarin

May increase anticoagulant effect (INR), monitor INR closely.

Probenecid

Increases cefixime plasma concentrations by decreasing renal excretion.

Carbamazepine

Elevated carbamazepine levels have been reported with co-administration.

Oral Contraceptives

Reduced effectiveness of oral contraceptives has been reported (though generally low risk).