SB-Losak
Generic Name
Losartan Potassium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sb losak 25 mg tablet | ৳ 4.50 | N/A |
| sb losak 50 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
SB-Losak (Losartan Potassium) is an angiotensin II receptor blocker (ARB) used to treat high blood pressure, diabetic nephropathy, and heart failure. It helps to relax blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, adjusted to 25-100 mg once daily based on blood pressure response.
Elderly
No initial dosage adjustment typically required, but consider lower starting dose (25 mg) if volume depleted or hepatic impairment.
Renal_impairment
No initial dosage adjustment required for mild to moderate renal impairment. For severe impairment or dialysis, consider lower starting dose (25 mg).
How to Take
Can be taken with or without food. Administer once daily at approximately the same time each day.
Mechanism of Action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor, primarily found in vascular smooth muscle and the adrenal gland. This blockage inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
About 6 hours for maximum effect, full blood pressure reduction in 3-6 weeks.
Excretion
Approximately 35% excreted in urine and 58% in feces, primarily as metabolites.
Half life
Losartan: 2 hours; Active metabolite (E-3174): 6-9 hours.
Absorption
Well absorbed orally, bioavailability about 33%. Peak plasma concentrations within 1 hour for Losartan and 3-4 hours for its active metabolite.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174) and several inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
Lithium
May increase lithium levels and toxicity.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce antihypertensive effect and increase risk of renal impairment.
Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene) or potassium supplements
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension and tachycardia; bradycardia could occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Category D (second and third trimesters). Avoid during lactation as Losartan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Losartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
Lithium
May increase lithium levels and toxicity.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce antihypertensive effect and increase risk of renal impairment.
Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene) or potassium supplements
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension and tachycardia; bradycardia could occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Category D (second and third trimesters). Avoid during lactation as Losartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Many clinical trials have established the efficacy and safety of Losartan in hypertension, diabetic nephropathy, and heart failure (e.g., LIFE study, RENAAL study).
Lab Monitoring
- Blood pressure monitoring
- Serum potassium levels
- Renal function (BUN, creatinine)
Doctor Notes
- Monitor blood pressure and renal function regularly.
- Advise patients about potential for dizziness and hyperkalemia.
- Contraindicated in pregnancy.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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