Seclo
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seclo 20 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Seclo 20 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It treats conditions such as heartburn, acid reflux, and stomach ulcers.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily, taken before a meal. For severe conditions, 40 mg once daily may be prescribed. H. pylori eradication requires specific combination therapy.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution should be exercised in severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule orally, preferably in the morning before breakfast. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
Omeprazole works by irreversibly binding to the H+/K+-ATPase pump (proton pump) in the parietal cells of the stomach. This inhibits the final step of acid production, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibition occurs within 1-2 hours.
Excretion
Mainly excreted in the urine (approximately 77%) as metabolites, with a smaller amount excreted in the feces.
Half life
Approximately 0.5-1 hour.
Absorption
Rapidly absorbed from the gastrointestinal tract, but bioavailability is incomplete (30-40%) due to first-pass metabolism. Bioavailability increases to approximately 60% with repeated dosing.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any components of the formulation
- Concomitant use of Nelfinavir
Drug Interactions
Warfarin
May increase INR and risk of bleeding.
Tacrolimus
May increase Tacrolimus plasma concentrations.
Clopidogrel
May reduce the antiplatelet effect of Clopidogrel.
Methotrexate
May increase Methotrexate levels, leading to toxicity.
Nelfinavir, Saquinavir
Reduced plasma concentrations of these antivirals.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts of Omeprazole are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any components of the formulation
- Concomitant use of Nelfinavir
Drug Interactions
Warfarin
May increase INR and risk of bleeding.
Tacrolimus
May increase Tacrolimus plasma concentrations.
Clopidogrel
May reduce the antiplatelet effect of Clopidogrel.
Methotrexate
May increase Methotrexate levels, leading to toxicity.
Nelfinavir, Saquinavir
Reduced plasma concentrations of these antivirals.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts of Omeprazole are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Omeprazole's efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and potential new applications.
Lab Monitoring
- Serum magnesium levels (especially with long-term use)
- Vitamin B12 levels (for prolonged therapy)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Assess patient for Helicobacter pylori infection if indicated.
- Consider lower doses for hepatic impairment.
- Monitor for long-term adverse effects, especially with extended therapy.
- Counsel patients on lifestyle modifications for GERD management.
Patient Guidelines
- Take your medicine exactly as prescribed by your doctor.
- Do not chew or crush the capsule; swallow it whole.
- Inform your doctor about all other medications you are taking.
- Complete the full course of treatment, even if symptoms improve.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger acid reflux (e.g., spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed while sleeping.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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