Seclo
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| seclo 40 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Seclo 40 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like heartburn, acid reflux (GERD), stomach ulcers, and to treat or prevent damage to the esophagus.
Uses & Indications
Dosage
Adults
For duodenal ulcer: 20 mg once daily for 2-4 weeks. For gastric ulcer: 20 mg once daily for 4-8 weeks. For GERD: 20 mg once daily for 4-8 weeks, severe cases 40 mg once daily. For Zollinger-Ellison Syndrome: Initial dose 60 mg once daily, adjusted as needed.
Elderly
No specific dose adjustment is required, but caution is advised in elderly patients, especially those with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Swallow the capsule whole with a glass of water, usually in the morning before breakfast. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) in the parietal cells of the stomach. This action effectively blocks the final step in gastric acid secretion, significantly reducing stomach acid levels.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1 hour, maximum effect within 2 hours.
Excretion
Approximately 80% of metabolites are excreted in the urine and about 20% in the feces.
Half life
Plasma elimination half-life is approximately 0.5 to 1.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 0.5 to 3.5 hours. Bioavailability is about 30-40%, increasing to about 60% with repeated doses due to saturation of presystemic metabolism.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 (CYP) enzyme system, specifically CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir (an antiretroviral drug)
Drug Interactions
Digoxin
Increased absorption and plasma levels of digoxin.
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma levels of methotrexate.
Nelfinavir, Atazanavir
Significantly reduced plasma levels of these antiretrovirals.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. There is no specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C (old FDA classification). Studies in pregnant women have shown no increased risk of major birth defects. Use during pregnancy only if clearly needed. Omeprazole is excreted in human breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir (an antiretroviral drug)
Drug Interactions
Digoxin
Increased absorption and plasma levels of digoxin.
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma levels of methotrexate.
Nelfinavir, Atazanavir
Significantly reduced plasma levels of these antiretrovirals.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. There is no specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C (old FDA classification). Studies in pregnant women have shown no increased risk of major birth defects. Use during pregnancy only if clearly needed. Omeprazole is excreted in human breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Omeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and new therapeutic applications.
Lab Monitoring
- Serum magnesium levels (especially with long-term use)
- Liver function tests (if hepatic impairment is suspected)
- Vitamin B12 levels (for prolonged therapy)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Evaluate for underlying conditions (e.g., C. difficile infection) if diarrhea persists.
- Consider magnesium supplementation and B12 monitoring in long-term users.
- Counsel patients on bone health, particularly those at risk for osteoporosis.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not crush, chew, or open the capsule; swallow it whole.
- Take at least 30 minutes before a meal, preferably in the morning.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole is generally not expected to affect the ability to drive or operate machinery. However, side effects such as dizziness or visual disturbances may occur; if so, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn or acid reflux (e.g., spicy foods, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed to reduce night-time reflux.
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