Segorin
Generic Name
Ondansetron
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| segorin 125 mg suspension | ৳ 230.00 | N/A |
Description
Overview of the medicine
Segorin-125 mg Suspension contains Ondansetron, a potent and highly selective 5-HT3 receptor antagonist. It is primarily used for the prevention and treatment of nausea and vomiting, especially those associated with chemotherapy, radiotherapy, and surgery. The 125 mg strength indicates a specific formulation, possibly referring to the total content in a bottle, designed for flexible dosing or for specific patient needs, and should be administered as per a physician's strict instructions regarding concentration and dose.
Uses & Indications
Dosage
Adults
Dosage varies significantly based on indication and formulation. Typical oral doses for Ondansetron are 4 mg or 8 mg. For chemotherapy-induced nausea and vomiting (CINV): 8 mg orally 30 minutes before chemotherapy, then 8 mg every 8-12 hours for 1-2 days. For PONV: 8 mg orally one hour before anesthesia, or 4 mg to 8 mg orally every 8 hours as needed. If 'Segorin-125 mg Suspension' implies a high concentration or total content, a physician must provide specific dilution and dosing instructions.
Elderly
No specific dose adjustment is generally required in the elderly; however, caution is advised in patients with impaired hepatic function.
Renal_impairment
No dose adjustment is generally required for patients with renal impairment.
Hepatic_impairment
In patients with moderate to severe hepatic impairment, the total daily dose should not exceed 8 mg.
How to Take
Shake the bottle well before each use. Administer the prescribed dose using a measuring spoon or oral syringe. Can be taken with or without food. Follow physician's instructions carefully regarding dilution or specific dosing, especially for this particular strength.
Mechanism of Action
Ondansetron selectively blocks the serotonin 5-HT3 receptors located both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the brain. By blocking these receptors, it inhibits the initiation of the vomiting reflex, effectively preventing nausea and vomiting.
Pharmacokinetics
Onset
Oral: 30 minutes to 2 hours
Excretion
Approximately 5% of the dose is excreted unchanged in urine; about 65% is eliminated as metabolites in urine, and 35% in feces.
Half life
Approximately 3-5 hours (adults); up to 20 hours (neonates)
Absorption
Rapidly and completely absorbed from the gastrointestinal tract following oral administration; bioavailability is approximately 60% due to first-pass metabolism.
Metabolism
Extensive hepatic metabolism, primarily via hydroxylation followed by glucuronide or sulfate conjugation. CYP1A2, CYP2D6, and CYP3A4 enzymes are involved.
Side Effects
Contraindications
- Hypersensitivity to Ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol; also increases risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron levels due to CYP induction.
QT-prolonging drugs (e.g., Amiodarone, Sotalol)
Increases risk of QT prolongation and Torsades de Pointes.
Storage
Store at room temperature (20-25°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy should be avoided, particularly in the first trimester, unless clearly necessary. Lactation: Ondansetron is excreted into breast milk. Breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to Ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol; also increases risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron levels due to CYP induction.
QT-prolonging drugs (e.g., Amiodarone, Sotalol)
Increases risk of QT prolongation and Torsades de Pointes.
Storage
Store at room temperature (20-25°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Treatment is symptomatic and supportive. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy: Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy should be avoided, particularly in the first trimester, unless clearly necessary. Lactation: Ondansetron is excreted into breast milk. Breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, typically 28 days after opening (if applicable for suspension).
Availability
Pharmacies, hospitals
Approval Status
Approved (General status for Ondansetron)
Patent Status
Generic available (Patent expired for Ondansetron)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Ondansetron's efficacy and safety for CINV, RINV, and PONV.
Lab Monitoring
- No specific routine lab monitoring is required. ECG monitoring is recommended in patients with underlying cardiac conditions, electrolyte abnormalities, or those taking other QT-prolonging drugs.
Doctor Notes
- Counsel patients on proper measurement and administration of oral suspension, especially given the specific 125 mg strength which may require careful dilution.
- Be aware of potential QT prolongation, especially in patients with pre-existing cardiac conditions or on concomitant QT-prolonging medications.
- Monitor for serotonin syndrome when used with other serotonergic agents.
Patient Guidelines
- Always shake the bottle well before measuring each dose.
- Use the provided measuring device (spoon or syringe) for accurate dosing.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ondansetron can cause dizziness or fatigue. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration, especially if experiencing vomiting. Avoid alcohol during treatment as it may exacerbate nausea or interact with medication.
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