Segorin
Generic Name
Calcium Dobesilate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| segorin 250 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Segorin 250 mg Tablet contains Calcium Dobesilate, a vasoprotective agent. It is primarily used to treat microangiopathies, such as diabetic retinopathy, and chronic venous insufficiency, reducing capillary permeability and improving blood flow.
Uses & Indications
Dosage
Adults
Typically 500-1000 mg daily, divided into 2-3 doses, taken with meals. Dosage may vary based on condition severity.
Elderly
No specific dose adjustment required, but caution is advised in patients with severe renal impairment.
Renal_impairment
Dosage reduction may be necessary in severe renal insufficiency. Consult physician.
How to Take
Oral administration. Tablets should be swallowed whole with water, preferably during or after meals to minimize gastrointestinal upset.
Mechanism of Action
Calcium Dobesilate acts by decreasing capillary permeability and fragility, inhibiting platelet aggregation, and reducing blood viscosity. It improves microcirculation by strengthening capillary walls and reducing leakage.
Pharmacokinetics
Onset
Clinical effects may take several weeks to manifest, as it acts on structural microvascular changes.
Excretion
Mainly excreted unchanged in urine (50%) and feces (50%).
Half life
Approximately 5 hours.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached within 6 hours.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Calcium Dobesilate or any excipients
- Severe renal impairment requiring dialysis
Drug Interactions
NSAIDs
No significant interactions reported, but caution advised with concomitant use.
Anticoagulants
May potentiate the effects of anticoagulants, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptomatic and supportive treatment is recommended. Gastric lavage may be considered if taken recently in large quantities.
Pregnancy & Lactation
Pregnancy category B. Use only if clearly needed and the potential benefits outweigh the potential risks. Excreted into breast milk, caution advised in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Calcium Dobesilate or any excipients
- Severe renal impairment requiring dialysis
Drug Interactions
NSAIDs
No significant interactions reported, but caution advised with concomitant use.
Anticoagulants
May potentiate the effects of anticoagulants, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose. Symptomatic and supportive treatment is recommended. Gastric lavage may be considered if taken recently in large quantities.
Pregnancy & Lactation
Pregnancy category B. Use only if clearly needed and the potential benefits outweigh the potential risks. Excreted into breast milk, caution advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved in Bangladesh
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy of Calcium Dobesilate in improving microcirculation and treating conditions like diabetic retinopathy and chronic venous insufficiency, showing favorable safety profile.
Lab Monitoring
- Complete blood count (CBC) if symptoms of agranulocytosis occur (e.g., fever, sore throat).
- Liver function tests in rare cases of suspected hepatotoxicity.
Doctor Notes
- Advise patients on the importance of adherence, as microvascular benefits may take time to become apparent.
- Counsel on recognizing rare but serious side effects like agranulocytosis (fever, infection signs).
- Consider baseline and periodic CBCs for long-term therapy, especially in at-risk patients, though not routinely recommended.
Patient Guidelines
- Follow your doctor's instructions carefully.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Calcium Dobesilate is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid prolonged standing or sitting to help with venous insufficiency.
- Manage underlying conditions like diabetes effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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