Adults

Most infections: 250-500 mg twice daily. Uncomplicated urinary tract infections: 125-250 mg twice daily. Gonorrhoea: 1000 mg as a single dose.

Elderly

Similar to adult dosage, but dose adjustment may be necessary in case of renal impairment.

Renal_impairment

Dosage should be reduced based on creatinine clearance (e.g., 125-250 mg once daily for severe impairment).

Onset

Rapid absorption with peak plasma concentrations occurring 2-3 hours after an oral dose.

Excretion

Excreted unchanged in urine, primarily via glomerular filtration and tubular secretion.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime. Oral bioavailability is approximately 37-52% when taken with food.

Metabolism

Not significantly metabolized in humans. The axetil moiety is hydrolyzed in the intestinal mucosa and blood.

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.

Antacids/H2 blockers/PPIs

Drugs that reduce gastric acidity may decrease the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least 2 hours before or after antacids, H2 blockers, or proton pump inhibitors.