Medicine Information

Sergel

Name: Sergel
Brand: Sergel

Capsule20 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
sergel 20 mg capsule	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Sergel capsule contains Esomeprazole, a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach.

Uses & Indications

Gastro-oesophageal Reflux Disease (GORD)

Erosive Esophagitis

Zollinger-Ellison Syndrome

Eradication of Helicobacter pylori (in combination with antibiotics)

Prevention and treatment of NSAID-associated gastric ulcers

Dosage

Adults

GORD: 20-40 mg once daily. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily with appropriate antibiotics.

Elderly

No specific dose adjustment is generally required, but caution is advised in patients with severe renal or hepatic impairment.

Renal_impairment

No dose adjustment necessary for patients with renal impairment.

How to Take

Swallow the capsule whole, at least 1 hour before a meal. Do not chew or crush the capsule.

Mechanism of Action

Esomeprazole selectively and irreversibly blocks the H+/K+ ATPase enzyme (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.

Pharmacokinetics

Onset

Within 1 hour.

Excretion

Approximately 80% renally and 20% in faeces.

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed, bioavailability is approximately 50-68%. Food intake delays and decreases absorption.

Metabolism

Extensively metabolized in the liver by CYP2C19 and CYP3A4 enzymes.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel.

Methotrexate

May increase methotrexate levels, requiring dose adjustment.

Diazepam, Phenytoin, Citalopram

May increase plasma levels of these drugs.

Ketoconazole, Itraconazole, Erlotinib

Reduced absorption due to increased gastric pH.

Storage

Store below 30°C, protect from moisture and light.

Overdose

Experience with overdose is limited. Symptomatic and supportive treatment should be provided.

Pregnancy & Lactation

Pregnancy Category C. Use with caution during pregnancy. Esomeprazole is excreted in breast milk; use with caution in nursing mothers.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel.

Methotrexate

May increase methotrexate levels, requiring dose adjustment.

Diazepam, Phenytoin, Citalopram

May increase plasma levels of these drugs.

Ketoconazole, Itraconazole, Erlotinib

Reduced absorption due to increased gastric pH.

Storage

Store below 30°C, protect from moisture and light.

Overdose

Experience with overdose is limited. Symptomatic and supportive treatment should be provided.

Pregnancy & Lactation

Pregnancy Category C. Use with caution during pregnancy. Esomeprazole is excreted in breast milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per blister30 capsules (3 blisters) per box

Shelf Life

2-3 years

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have been conducted for its efficacy in GORD, ulcer healing, and H. pylori eradication.

Lab Monitoring

For long-term use: Monitor magnesium levels, vitamin B12 levels.

Doctor Notes

Consider duration of therapy and lowest effective dose.
Be aware of potential drug interactions, especially with clopidogrel and warfarin.
Monitor for long-term complications like hypomagnesemia and B12 deficiency.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not chew or crush the capsules.
Report any severe or persistent side effects to your doctor.
Complete the full course of treatment even if symptoms improve.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.