Sergel
Generic Name
Esomeprazole 40 mg Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sergel 40 mg injection | ৳ 100.00 | N/A |
Description
Overview of the medicine
Sergel 40 mg Injection contains Esomeprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, duodenal ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
40 mg once daily by intravenous infusion for 7-10 days, then transition to oral therapy. For Zollinger-Ellison syndrome, initial dose 80 mg daily, then individualized.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution is advised in those with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Administer by intravenous infusion over a period of 10 to 30 minutes after reconstitution. Do not administer by intravenous bolus or intramuscular injection.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that works by irreversibly binding to the H+/K+-ATPase enzyme system (the proton pump) on the secretory surface of the gastric parietal cells. This inhibits the final step in acid production, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour after intravenous administration.
Excretion
Metabolites are primarily excreted in the urine (approximately 80%) and in the feces (approximately 20%).
Half life
Approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after intravenous administration, demonstrating high systemic bioavailability.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin. Monitor digoxin levels.
Warfarin
Increased INR and prothrombin time have been reported with concomitant use. Monitor INR.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19. Avoid concomitant use if possible.
Methotrexate
May increase serum methotrexate levels, particularly with high doses. Consider temporary withdrawal of esomeprazole.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals, potentially leading to loss of therapeutic effect. Contraindicated with nelfinavir.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Reconstituted solution should be used within 6 hours.
Overdose
Limited experience with overdose. Symptoms reported with oral overdose are largely reversible and include gastrointestinal disturbances and weakness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is likely excreted in human milk; use with caution in breastfeeding women.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin. Monitor digoxin levels.
Warfarin
Increased INR and prothrombin time have been reported with concomitant use. Monitor INR.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19. Avoid concomitant use if possible.
Methotrexate
May increase serum methotrexate levels, particularly with high doses. Consider temporary withdrawal of esomeprazole.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals, potentially leading to loss of therapeutic effect. Contraindicated with nelfinavir.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Reconstituted solution should be used within 6 hours.
Overdose
Limited experience with overdose. Symptoms reported with oral overdose are largely reversible and include gastrointestinal disturbances and weakness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is likely excreted in human milk; use with caution in breastfeeding women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for molecule
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of esomeprazole in the treatment of GERD, erosive esophagitis, duodenal ulcers, and Zollinger-Ellison syndrome.
Lab Monitoring
- Magnesium levels (especially with prolonged use or concomitant diuretics)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Intravenous esomeprazole is indicated for short-term treatment of GERD, or when oral administration is not possible.
- Transition to oral therapy as soon as clinically appropriate.
- Monitor for potential drug interactions, especially with warfarin, clopidogrel, and atazanavir/nelfinavir.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking this medicine abruptly without consulting your doctor, as it may lead to a relapse of symptoms.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or visual disturbances. If you experience these side effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger your symptoms, such as fatty foods, spicy foods, caffeine, and alcohol.
- Elevate the head of your bed to reduce reflux symptoms, especially at night.
- Maintain a healthy weight and quit smoking for better management of acid-related conditions.
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