Silox
Generic Name
Cefuroxime Axetil 250 mg Capsule
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| silox 250 mg capsule | ৳ 5.77 | N/A |
Description
Overview of the medicine
Cefuroxime Axetil is a broad-spectrum antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Most infections: 250 mg twice daily for 7-10 days. Severe infections or bronchitis: 500 mg twice daily for 7-10 days. Uncomplicated UTI: 125 mg twice daily for 7-10 days. Uncomplicated Gonorrhea: 1000 mg as a single dose.
Elderly
No specific dose adjustment needed unless severe renal impairment. Refer to renal impairment guidelines.
Renal_impairment
Creatinine clearance 30 mL/min or greater: No dose adjustment needed. Creatinine clearance <30 mL/min: Reduce dose or increase dosing interval. For example, 250 mg once daily for most infections.
How to Take
For oral administration. To optimize absorption, Cefuroxime Axetil should be taken with food. Do not crush or chew the capsule; swallow whole.
Mechanism of Action
Cefuroxime Axetil inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Typically, therapeutic plasma concentrations are achieved within 1-2 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine, approximately 50% by glomerular filtration and 50% by tubular secretion.
Half life
Approximately 1.2 to 1.5 hours in adults with normal renal function.
Absorption
Rapidly absorbed from the gastrointestinal tract and hydrolyzed to cefuroxime. Enhanced absorption when taken with food.
Metabolism
Cefuroxime is not significantly metabolized in the liver; it is hydrolyzed in the intestinal mucosa and blood to active cefuroxime.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by approximately 50%.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Patients should be advised to consider alternative or additional contraceptive methods.
Antacids/H2-receptor antagonists
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil. It is recommended to administer cefuroxime axetil at least 1-2 hours apart from these agents.
Aminoglycosides and potent diuretics
Concurrent administration with aminoglycosides or potent diuretics may increase the risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include cerebral irritation leading to convulsions. Management is supportive, and hemodialysis may be effective in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems, monobactams).
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by approximately 50%.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Patients should be advised to consider alternative or additional contraceptive methods.
Antacids/H2-receptor antagonists
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil. It is recommended to administer cefuroxime axetil at least 1-2 hours apart from these agents.
Aminoglycosides and potent diuretics
Concurrent administration with aminoglycosides or potent diuretics may increase the risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include cerebral irritation leading to convulsions. Management is supportive, and hemodialysis may be effective in removing cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Cefuroxime is excreted in breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic Available
WHO Essential Medicine
YesClinical Trials
Cefuroxime Axetil has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections in adults and pediatric populations.
Lab Monitoring
- Renal function (creatinine clearance) in patients with impaired kidney function.
- Liver function tests (ALT, AST) if liver abnormalities are suspected (rare).
Doctor Notes
- Emphasize the importance of completing the full course to prevent bacterial resistance.
- Advise patients about potential gastrointestinal side effects and the importance of taking with food.
- Be alert for signs of C. difficile infection if patient presents with severe diarrhea.
Patient Guidelines
- Take the medicine with food to improve absorption and reduce stomach upset.
- Complete the entire course of treatment as prescribed by your doctor, even if symptoms improve.
- Do not save unused antibiotics for future infections.
- Inform your doctor if you develop severe or persistent diarrhea during or after treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness; patients should be aware of how they react to this medication before driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol, as it may exacerbate gastrointestinal side effects.
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