Sinapol
Generic Name
Paracetamol 120 mg/5 mL Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinapol 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Sinapol 120 mg Suspension contains Paracetamol, an analgesic and antipyretic, used to relieve mild to moderate pain and reduce fever in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this specific concentration; adult formulations are higher strength.
Elderly
Use with caution; consult a physician for appropriate dosage.
Renal_impairment
Dosage adjustment may be necessary; consult a physician.
How to Take
Oral. Administer with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Paracetamol is thought to act primarily by inhibiting prostaglandin synthesis in the central nervous system, which helps reduce pain and fever. It also produces antipyresis by acting centrally on the hypothalamic heat-regulating center.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesia, 30 minutes for antipyresis.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates, with a small amount excreted unchanged.
Half life
Approximately 1-3 hours in adults.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver by conjugation with glucuronic acid and sulfate, and to a lesser extent by the cytochrome P450 enzyme system to a toxic intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the suspension
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of liver damage, especially with chronic heavy use.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Phenobarbital, Phenytoin, Carbamazepine
May increase risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (hepatotoxicity). Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe at recommended doses for short-term use. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the suspension
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases risk of liver damage, especially with chronic heavy use.
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Phenobarbital, Phenytoin, Carbamazepine
May increase risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (hepatotoxicity). Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe at recommended doses for short-term use. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, specific to batch.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical data available given its long history of use. New trials may focus on specific formulations or populations.
Lab Monitoring
- Liver function tests (in cases of overdose or prolonged use)
- Renal function tests (in cases of renal impairment)
Doctor Notes
- Advise parents on accurate dosing using appropriate measuring devices.
- Emphasize not to exceed maximum daily dose due to hepatotoxicity risk.
Patient Guidelines
- Do not exceed the recommended dose.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally none, as paracetamol does not typically cause drowsiness or impair driving ability at therapeutic doses.
Lifestyle Advice
- Stay hydrated.
- Rest adequately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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