Sinapol
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Kalponik Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinapol 500 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Sinapol-500 mg tablet contains Paracetamol, a widely used medication for relieving mild to moderate pain and reducing fever.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed, not exceeding 4000 mg (8 tablets) in 24 hours.
Elderly
Similar to adult dosage, but caution advised in patients with impaired hepatic or renal function.
Renal_impairment
Dose adjustment or increased dosing interval may be necessary in severe renal impairment.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Paracetamol (Acetaminophen) primarily acts by inhibiting prostaglandin synthesis in the central nervous system, leading to its analgesic and antipyretic effects.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Excreted mainly by the kidneys as glucuronide and sulfate conjugates.
Half life
Plasma half-life ranges from 1 to 4 hours.
Absorption
Rapid and complete absorption from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by CYP2E1 to a toxic intermediate, NAPQI, which is normally detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity with paracetamol.
Warfarin
May enhance the anticoagulant effect of warfarin, leading to increased bleeding risk.
Phenytoin, Carbamazepine, Phenobarbital
May increase the metabolism of paracetamol, reducing its effectiveness and increasing risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal hepatotoxicity. Symptoms may include nausea, vomiting, abdominal pain, and liver failure. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe at recommended doses during pregnancy and lactation, but always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity with paracetamol.
Warfarin
May enhance the anticoagulant effect of warfarin, leading to increased bleeding risk.
Phenytoin, Carbamazepine, Phenobarbital
May increase the metabolism of paracetamol, reducing its effectiveness and increasing risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal hepatotoxicity. Symptoms may include nausea, vomiting, abdominal pain, and liver failure. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe at recommended doses during pregnancy and lactation, but always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, supermarkets, general stores
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied in numerous clinical trials and has a long history of safe and effective use. Ongoing research continues to explore its efficacy and safety profile in various populations and conditions.
Lab Monitoring
- Liver function tests (especially in cases of prolonged use, high doses, or suspected overdose)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Advise patients not to exceed the maximum daily dose of 4g to prevent hepatotoxicity.
- Educate patients on identifying paracetamol in combination products to avoid accidental overdose.
- Monitor liver function tests in patients on chronic therapy or with pre-existing liver conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking other medicines containing paracetamol simultaneously.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Paracetamol does not typically cause drowsiness or affect the ability to drive or operate machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication, especially if at risk of liver problems.
- Stay hydrated.
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Global Brand Names
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