Sinapol
Generic Name
Paracetamol
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinapol 120 mg syrup | ৳ 50.00 | N/A |
Description
Overview of the medicine
Sinapol 120 mg syrup contains Paracetamol, an analgesic and antipyretic used to relieve pain and reduce fever. It is commonly used for infants and children.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this strength; higher strengths available for adults. However, if used, 10-15 mg/kg body weight, 3-4 times daily.
Elderly
Similar to adult dosage; caution with hepatic/renal impairment.
Children
10-15 mg/kg body weight, 3-4 times daily. Maximum 60 mg/kg/day.
Renal_impairment
Dosage interval may need to be extended. Consult a physician.
How to Take
Oral. Administer with or without food. Use a measuring spoon or oral syringe for accurate dosing, especially for children.
Mechanism of Action
Paracetamol inhibits prostaglandin synthesis primarily in the central nervous system, which contributes to its analgesic and antipyretic effects.
Pharmacokinetics
Onset
Pain relief usually within 30-60 minutes, fever reduction within 30 minutes.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates.
Half life
1-3 hours in adults, slightly longer in neonates.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 to a toxic intermediate, NAPQI, which is then conjugated with glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic heavy alcohol use
Warfarin
May increase anticoagulant effect
Storage
Store below 30°C in a dry place, away from direct sunlight.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at therapeutic doses. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic heavy alcohol use
Warfarin
May increase anticoagulant effect
Storage
Store below 30°C in a dry place, away from direct sunlight.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at therapeutic doses. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic (Patent Expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical data supports the efficacy and safety of Paracetamol for fever and pain relief.
Lab Monitoring
- Liver function tests (in case of prolonged use or overdose)
- Renal function tests (in patients with kidney impairment)
Doctor Notes
- Advise parents on correct dosing based on child's weight.
- Emphasize not to exceed maximum daily dose due to hepatotoxicity risk.
Patient Guidelines
- Do not exceed the recommended dose.
- Keep out of reach of children.
- Consult a doctor if symptoms persist for more than 3 days.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate hydration.
- Rest when having fever or pain.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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