Sizodon
Generic Name
Risperidone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sizodon 2 mg tablet | ৳ 6.02 | ৳ 60.20 |
Description
Overview of the medicine
Sizodon 2 mg tablet contains Risperidone, an atypical antipsychotic medication used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 0.5-2 mg/day, gradually increased to 4-8 mg/day in 1-2 divided doses. Max 16 mg/day. Bipolar mania: Initially 2-3 mg/day, gradually increased as needed. Autistic irritability: Initially 0.25 mg BID, titrated up to 0.5-1 mg/day.
Elderly
Lower initial doses (e.g., 0.5 mg BID) and slower titration recommended.
Renal_impairment
Initial dose 0.5 mg BID, then carefully titrate up to 1-2 mg BID.
How to Take
Sizodon 2 mg tablet can be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Risperidone acts as a potent antagonist at serotonin 5-HT2 and dopamine D2 receptors. It also antagonizes alpha1-adrenergic and H1-histaminergic receptors. Its antipsychotic activity is believed to be mediated through a combination of D2 and 5-HT2 antagonism.
Pharmacokinetics
Onset
Within 1-2 weeks for antipsychotic effect, though some effects may be seen earlier.
Excretion
Excreted primarily in urine (70%) and feces (14%) as risperidone and its metabolites.
Half life
Risperidone: approximately 3 hours; active metabolite (9-hydroxyrisperidone): approximately 21 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 2D6 (CYP2D6) to 9-hydroxyrisperidone, which is equally active. Also N-dealkylation.
Side Effects
Contraindications
- •Hypersensitivity to Risperidone or any component of the formulation.
- •History of neuroleptic malignant syndrome (NMS).
Drug Interactions
Antihypertensives
Additive hypotensive effects.
Dopamine agonists (e.g., levodopa)
May antagonize the effects of dopamine agonists.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased CNS depressant effects.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Treatment is supportive; maintain airway, monitor cardiac function, and provide symptomatic therapy.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding due to excretion into breast milk and potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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