Take one capsule orally at least one hour before a meal, preferably in the morning. Swallow the capsule whole with water; do not chew, crush, or open it. If difficulty swallowing, the capsule can be opened and the contents mixed with a small amount of water or soft food and consumed immediately.

Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. This inhibition prevents the final step of acid secretion, leading to a reduction in gastric acidity.

• •Known hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
• •Concomitant use with nelfinavir (an antiretroviral drug).

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

In case of overdose, symptoms are generally mild and may include drowsiness, tachycardia, nausea, and abdominal pain. There is no specific antidote. Treatment should be symptomatic and supportive.

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; caution should be exercised when administered to a nursing mother.