Sugatrol
Generic Name
Glimepiride
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sugatrol 50 mg tablet | ৳ 15.00 | ৳ 150.00 |
| sugatrol 100 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Sugatrol is an oral hypoglycemic agent containing Glimepiride, used to lower blood glucose levels in patients with type 2 diabetes mellitus when diet and exercise alone are not sufficient.
Uses & Indications
Dosage
Adults
Initial dose: 1-2 mg once daily. Maintenance dose: 1-4 mg once daily. Max dose: 8 mg once daily.
Elderly
Start with 1 mg once daily, titrate carefully. Avoid doses > 4 mg daily.
Renal_impairment
Initial dose 1 mg once daily, titrate carefully based on renal function and glycemic control. Max dose 4 mg daily if GFR > 22 mL/min. Not recommended for severe impairment.
How to Take
Taken orally, usually once daily with breakfast or the first main meal of the day.
Mechanism of Action
Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta cells. It binds to the sulfonylurea receptor on the beta cell, leading to closure of ATP-sensitive potassium channels, membrane depolarization, and calcium influx, which triggers insulin secretion. It may also have some extrapancreatic effects.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (60%) and feces (40%) as metabolites.
Half life
Approximately 5-9 hours
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations reached within 2-3 hours.
Metabolism
Completely metabolized by oxidative biotransformation (primarily by CYP2C9) to two main metabolites: a cyclohexylhydroxy-methyl derivative and a carboxyl derivative.
Side Effects
Contraindications
- Known hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, with or without coma.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Alcohol
May potentiate or weaken hypoglycemic action.
Insulin and other oral antidiabetics
Increased hypoglycemic effect.
Corticosteroids, Diuretics, Estrogens, Thyroid hormones
Weaken hypoglycemic effect.
NSAIDs, ACE inhibitors, MAO inhibitors, Beta-blockers, Sulfonamides
Potentiate hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypoglycemia, which may lead to coma, seizures, or other neurological impairment. Management involves immediate glucose administration (oral or IV), monitoring blood glucose levels, and supportive care.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant and risk of hypoglycemia. Insulin is generally preferred for blood glucose control during pregnancy.
Side Effects
Contraindications
- Known hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, with or without coma.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Alcohol
May potentiate or weaken hypoglycemic action.
Insulin and other oral antidiabetics
Increased hypoglycemic effect.
Corticosteroids, Diuretics, Estrogens, Thyroid hormones
Weaken hypoglycemic effect.
NSAIDs, ACE inhibitors, MAO inhibitors, Beta-blockers, Sulfonamides
Potentiate hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypoglycemia, which may lead to coma, seizures, or other neurological impairment. Management involves immediate glucose administration (oral or IV), monitoring blood glucose levels, and supportive care.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant and risk of hypoglycemia. Insulin is generally preferred for blood glucose control during pregnancy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies and hospitals in Bangladesh
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generics available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Glimepiride in managing type 2 diabetes mellitus. Ongoing research may explore long-term outcomes and comparative effectiveness.
Lab Monitoring
- Blood glucose levels regularly.
- HbA1c levels every 3-6 months.
- Renal and hepatic function periodically.
- Complete blood count (CBC) periodically.
Doctor Notes
- Educate patients on hypoglycemia symptoms and management.
- Regularly assess renal function, especially in elderly patients.
- Consider combination therapy if monotherapy is insufficient for glycemic control.
Patient Guidelines
- Take Sugatrol exactly as prescribed by your doctor.
- Do not crush or chew tablets.
- Monitor your blood glucose regularly.
- Carry a source of sugar (e.g., glucose tablets, juice) to treat mild hypoglycemia.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Patients should be aware of the symptoms of hypoglycemia, which may impair their ability to concentrate and react. Caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Manage stress effectively.
- Regular follow-ups with your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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