Taxim
Generic Name
Cefotaxime 250 mg Injection
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taxim 250 mg injection | ৳ 75.22 | N/A |
Description
Overview of the medicine
Taxim 250 mg Injection contains Cefotaxime, a broad-spectrum third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
General dosage: 1-2 grams every 8-12 hours, administered IM or IV. Severe infections may require higher doses up to 12 grams/day in divided doses.
Elderly
Similar to adult dosage, but dose adjustment may be necessary based on renal function.
Renal_impairment
Dosage reduction is required for patients with significant renal impairment (creatinine clearance < 20 ml/min). Max 2g daily for severe impairment.
How to Take
For intravenous (IV) administration, it can be given as a slow injection over 3-5 minutes or as an infusion over 20-60 minutes. For intramuscular (IM) administration, it should be injected deeply into a large muscle mass.
Mechanism of Action
Cefotaxime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death (bactericidal action).
Pharmacokinetics
Onset
Rapid (within minutes for IV administration).
Excretion
Mainly excreted by the kidneys (approx. 50-60% as unchanged drug and 15-25% as desacetylcefotaxime within 24 hours).
Half life
Approximately 1-1.5 hours for the parent drug; 1.5-2 hours for the active metabolite desacetylcefotaxime.
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration.
Metabolism
Primarily hepatic metabolism to an active metabolite, desacetylcefotaxime.
Side Effects
Contraindications
- Hypersensitivity to cefotaxime or other cephalosporins.
- History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillins).
Drug Interactions
Probenecid
Increases and prolongs cefotaxime plasma concentrations by reducing renal tubular secretion.
Loop Diuretics
May increase the risk of nephrotoxicity when given concurrently with other nephrotoxic drugs.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered.
Storage
Store below 25-30°C. Protect from light and moisture. Keep out of reach of children. Reconstituted solutions should be used immediately or within specified time if refrigerated.
Overdose
Overdose symptoms may include encephalopathy, convulsions, and neuromuscular excitability. Management is primarily symptomatic and supportive. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Cefotaxime is excreted in breast milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefotaxime or other cephalosporins.
- History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillins).
Drug Interactions
Probenecid
Increases and prolongs cefotaxime plasma concentrations by reducing renal tubular secretion.
Loop Diuretics
May increase the risk of nephrotoxicity when given concurrently with other nephrotoxic drugs.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered.
Storage
Store below 25-30°C. Protect from light and moisture. Keep out of reach of children. Reconstituted solutions should be used immediately or within specified time if refrigerated.
Overdose
Overdose symptoms may include encephalopathy, convulsions, and neuromuscular excitability. Management is primarily symptomatic and supportive. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Cefotaxime is excreted in breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored correctly. Reconstituted solution has a shorter shelf life.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Patent expired, available as generic
WHO Essential Medicine
YesClinical Trials
Cefotaxime has been extensively studied in numerous clinical trials establishing its efficacy and safety profile for various bacterial infections.
Lab Monitoring
- Renal function tests (BUN, creatinine) in patients with renal impairment.
- Liver function tests (AST, ALT, ALP) in prolonged therapy.
- Complete blood count (CBC) during extended treatment courses.
Doctor Notes
- Confirm bacterial susceptibility with culture and sensitivity tests prior to initiation, if possible.
- Monitor for signs of superinfection during prolonged therapy.
- Adjust dose in patients with renal impairment to prevent accumulation and potential toxicity.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Report any unusual side effects or signs of allergic reaction immediately to your doctor.
- Do not save unused medication for future infections.
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefotaxime may cause dizziness or encephalopathy in some individuals, particularly with high doses or in patients with renal impairment. Caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infections.
- Drink plenty of fluids unless otherwise advised by your doctor.
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