Taxim
Generic Name
taxim-500-mg-injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taxim 500 mg injection | ৳ 100.30 | N/A |
Description
Overview of the medicine
Cefotaxime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Usually 500 mg - 1 g IV/IM every 8-12 hours, up to 2 g every 4-8 hours for severe infections. Dosage should not exceed 12 g/day.
Elderly
Dosage adjustment may be required based on renal function.
Renal_impairment
Dosage reduction is necessary based on creatinine clearance.
How to Take
Administer intravenously (slowly over 3-5 minutes or as infusion over 20-60 minutes) or intramuscularly (deep IM injection). Reconstitute powder with sterile water for injection.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Rapid (within minutes for IV administration).
Excretion
Mainly renal (via urine).
Half life
Approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after intramuscular (IM) or intravenous (IV) administration.
Metabolism
Primarily metabolized in the liver to desacetylcefotaxime (active metabolite).
Side Effects
Contraindications
- Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity to penicillin (due to potential cross-allergenicity).
Drug Interactions
Probenecid
May increase cefotaxime plasma concentrations.
Aminoglycosides
Increased risk of nephrotoxicity; monitor renal function.
Oral anticoagulants
May potentiate the effects of oral anticoagulants (e.g., warfarin).
Storage
Store below 25-30°C. Protect from light. Reconstituted solution should be used immediately or within a specified time if refrigerated.
Overdose
Management is supportive and symptomatic. Hemodialysis may be useful in reducing serum cefotaxime concentrations.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity to penicillin (due to potential cross-allergenicity).
Drug Interactions
Probenecid
May increase cefotaxime plasma concentrations.
Aminoglycosides
Increased risk of nephrotoxicity; monitor renal function.
Oral anticoagulants
May potentiate the effects of oral anticoagulants (e.g., warfarin).
Storage
Store below 25-30°C. Protect from light. Reconstituted solution should be used immediately or within a specified time if refrigerated.
Overdose
Management is supportive and symptomatic. Hemodialysis may be useful in reducing serum cefotaxime concentrations.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check specific product for exact duration)
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Cefotaxime has been extensively studied since its introduction; data on its efficacy and safety in various bacterial infections are well-documented.
Lab Monitoring
- Renal function (especially in elderly or patients with pre-existing impairment)
- Liver function tests (periodically during prolonged therapy)
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Careful history taking regarding penicillin allergy is crucial due to potential cross-reactivity.
- Adjust dose in patients with significant renal impairment.
- Monitor for signs of superinfection, especially with prolonged use.
Patient Guidelines
- Complete the full course of antibiotic treatment as prescribed, even if symptoms improve.
- Report any severe allergic reactions or persistent side effects to your doctor immediately.
- Do not share this medication with others, and do not use it for conditions not prescribed.
Missed Dose Advice
Administer the missed dose as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness in some patients; advise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid alcohol if experiencing gastrointestinal side effects.
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