Taziaid
Generic Name
Ceftazidime
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taziaid 500 mg injection | ৳ 130.00 | N/A |
Description
Overview of the medicine
Ceftazidime is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is effective against a broad spectrum of gram-negative bacteria, including Pseudomonas aeruginosa, and some gram-positive organisms. It is administered parenterally, typically intravenously or intramuscularly.
Uses & Indications
Dosage
Adults
Typically 1-2 g intravenously or intramuscularly every 8-12 hours, depending on the severity of the infection and susceptibility of the pathogen. Maximum dose up to 6 g/day.
Elderly
No specific dose adjustment for elderly patients with normal renal function. Doses should be adjusted based on renal function.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For severe impairment, dose may be significantly reduced and/or interval extended.
How to Take
Administer by deep intramuscular injection or by slow intravenous injection (3-5 minutes) or by intravenous infusion (20-30 minutes). Reconstitute the powder with sterile water for injection, according to manufacturer's instructions.
Mechanism of Action
Ceftazidime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane, thereby interfering with the transpeptidation step of peptidoglycan synthesis. This leads to disruption of the cell wall, ultimately causing bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, within minutes of IV administration.
Excretion
Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 1.8-2 hours in adults with normal renal function.
Absorption
Rapid and complete absorption after intramuscular administration; peak plasma concentrations reached within approximately 1 hour. Intravenous administration results in immediate peak concentrations.
Metabolism
Not metabolized; excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to ceftazidime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Furosemide
Concomitant use with potent diuretics like furosemide may enhance nephrotoxicity.
Aminoglycosides
May increase nephrotoxicity, especially in patients with pre-existing renal impairment.
Chloramphenicol
Antagonistic effects may occur in vitro.
Storage
Store below 30°C. Protect from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored according to specific guidelines.
Overdose
Overdose symptoms may include neurological sequelae such as encephalopathy, convulsions, and coma. Treatment is symptomatic and supportive. Hemodialysis may be useful in removing the drug from the system.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Ceftazidime is excreted in small amounts into breast milk; use with caution during lactation. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to ceftazidime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Furosemide
Concomitant use with potent diuretics like furosemide may enhance nephrotoxicity.
Aminoglycosides
May increase nephrotoxicity, especially in patients with pre-existing renal impairment.
Chloramphenicol
Antagonistic effects may occur in vitro.
Storage
Store below 30°C. Protect from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored according to specific guidelines.
Overdose
Overdose symptoms may include neurological sequelae such as encephalopathy, convulsions, and coma. Treatment is symptomatic and supportive. Hemodialysis may be useful in removing the drug from the system.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Ceftazidime is excreted in small amounts into breast milk; use with caution during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as indicated on the package. Reconstituted solution has a shorter shelf life.
Availability
Hospitals, Pharmacies
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ceftazidime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Ongoing research continues to monitor its effectiveness against emerging resistant strains.
Lab Monitoring
- Renal function tests (BUN, creatinine) in patients with pre-existing renal impairment or receiving concomitant nephrotoxic drugs.
- Liver function tests (ALT, AST) periodically during prolonged therapy.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Crucial for empiric therapy in severe gram-negative infections, particularly involving Pseudomonas.
- Monitor renal function, especially in elderly or co-morbid patients.
- Beware of potential for C. difficile infection post-antibiotic therapy.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe or persistent side effects to your doctor.
- Do not use for viral infections.
Missed Dose Advice
If a dose is missed, it should be administered as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Ceftazidime can cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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