Telmicard
Generic Name
Telmisartan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telmicard 40 mg tablet | ৳ 8.00 | ৳ 112.00 |
| telmicard 80 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Telmicard is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in patients aged 55 years or older at high risk.
Uses & Indications
Dosage
Adults
Usually 40 mg orally once daily. Dosage may be increased to a maximum of 80 mg once daily if needed.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Administer orally once daily, with or without food.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and adrenal gland. This blockage inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Onset of antihypertensive effect within 3 hours; maximal reduction within 4-8 weeks.
Excretion
Almost entirely excreted in feces via bile; less than 1% excreted in urine.
Half life
Elimination half-life is approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is dose-dependent (approx. 42% for 40 mg, 58% for 160 mg). Food slightly reduces bioavailability.
Metabolism
Primarily metabolized via conjugation to form an inactive acylglucuronide.
Side Effects
Contraindications
- Pregnancy (especially 2nd and 3rd trimesters)
- Biliary obstructive disorders or severe hepatic impairment
- Hypersensitivity to telmisartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
NSAIDs
May reduce the antihypertensive effect and increase risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of renal impairment, hypotension, and hyperkalemia.
Diuretics
May enhance the hypotensive effect.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C (86°F) in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension, dizziness, tachycardia, or bradycardia. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telmicard is contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, it is not recommended during lactation.
Side Effects
Contraindications
- Pregnancy (especially 2nd and 3rd trimesters)
- Biliary obstructive disorders or severe hepatic impairment
- Hypersensitivity to telmisartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
NSAIDs
May reduce the antihypertensive effect and increase risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of renal impairment, hypotension, and hyperkalemia.
Diuretics
May enhance the hypotensive effect.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C (86°F) in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension, dizziness, tachycardia, or bradycardia. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Telmicard is contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, it is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Telmisartan has been studied in large clinical trials such as ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) which investigated its efficacy in cardiovascular risk reduction.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (serum creatinine, BUN)
- Liver function tests (if clinically indicated).
Doctor Notes
- Counsel patients on adherence, lifestyle changes, and monitoring BP.
- Caution in patients with bilateral renal artery stenosis.
- Regular monitoring of serum potassium and renal function is essential.
Patient Guidelines
- Take Telmicard exactly as prescribed by your doctor.
- Do not stop taking Telmicard without consulting your doctor, even if you feel well.
- Report any unusual side effects or symptoms to your doctor immediately.
- Monitor your blood pressure regularly as advised by your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Telmicard may cause dizziness or lightheadedness, especially when initiating therapy or increasing dosage. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as recommended by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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