Tempol
Generic Name
Paracetamol (Acetaminophen) 80 mg/mL Pediatric Drop
Manufacturer
Reputable Local Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tempol 80 mg pediatric drop | ৳ 12.31 | N/A |
Description
Overview of the medicine
Tempol 80 mg Pediatric Drop is used for the symptomatic relief of mild to moderate pain and fever in infants and young children. It contains Paracetamol (Acetaminophen) as its active ingredient.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drops. Adults typically use tablet/syrup formulations.
Elderly
Not applicable for pediatric drops.
Renal_impairment
For pediatric patients with severe renal impairment, dosage interval may need adjustment. Consult a physician.
How to Take
Administer orally using the calibrated dropper provided with the pack. Ensure correct dosage based on the child's weight or age. Can be given with or without food.
Mechanism of Action
Paracetamol primarily acts by inhibiting prostaglandin synthesis in the central nervous system, which contributes to its analgesic and antipyretic effects. It has minimal anti-inflammatory action.
Pharmacokinetics
Onset
Analgesic effect: 30-60 minutes. Antipyretic effect: 30-60 minutes.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Approximately 1.5 to 3 hours in adults; slightly shorter in children.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- Known hypersensitivity to Paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, leading to increased risk of bleeding, especially with prolonged, high-dose use.
Cholestyramine
Reduces absorption of paracetamol if given within an hour.
Other hepatotoxic drugs
Concomitant use with other drugs metabolized by the liver may increase the risk of liver damage.
Carbamazepine, Phenobarbital, Phenytoin
May increase the risk of paracetamol hepatotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating, potentially leading to hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
This is a pediatric product. For adults, Paracetamol is generally considered safe during pregnancy and lactation when used at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to Paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, leading to increased risk of bleeding, especially with prolonged, high-dose use.
Cholestyramine
Reduces absorption of paracetamol if given within an hour.
Other hepatotoxic drugs
Concomitant use with other drugs metabolized by the liver may increase the risk of liver damage.
Carbamazepine, Phenobarbital, Phenytoin
May increase the risk of paracetamol hepatotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating, potentially leading to hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
This is a pediatric product. For adults, Paracetamol is generally considered safe during pregnancy and lactation when used at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date, depending on manufacturer specifications.
Availability
Available in pharmacies and drug stores
Approval Status
Generally approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol is a well-established drug with extensive clinical use for decades. Specific clinical trials for this exact formulation generally focus on bioavailability, bioequivalence, and safety in pediatric populations.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of suspected overdose or prolonged high-dose use.
- Renal function tests if there's a risk of renal impairment.
Doctor Notes
- Emphasize accurate weight-based dosing for pediatric patients.
- Educate parents/caregivers on the risks of paracetamol overdose and avoidance of concomitant use with other paracetamol-containing products.
- Advise to seek medical advice if symptoms persist or worsen.
Patient Guidelines
- Always use the calibrated dropper for accurate dosing.
- Do not exceed the recommended dose or frequency.
- Do not use with other Paracetamol-containing products to avoid overdose.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Not applicable as this is a pediatric formulation for infants and young children.
Lifestyle Advice
- Ensure adequate fluid intake, especially when feverish.
- Dress children lightly when they have a fever.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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