Adults

Adults and children over 12 years or weighing >50 kg: 200-400 mg once daily or 200 mg every 12 hours. For 100 mg/5 ml suspension, this would be 10-20 ml once daily or 10 ml every 12 hours.

Elderly

No specific dose adjustment is needed unless severe renal impairment is present.

Children

Children 6 months to 12 years: 8 mg/kg/day once daily or 4 mg/kg every 12 hours. (Maximum 400 mg/day).

Renal_impairment

For creatinine clearance 21-60 mL/min: 75% of the standard dose. For creatinine clearance < 20 mL/min: 50% of the standard dose.

Onset

Peak plasma concentrations are achieved within 2-6 hours after oral administration.

Excretion

Primarily excreted in the urine (about 50%) and bile (about 10%) as unchanged drug.

Half life

The plasma elimination half-life is typically 3-4 hours, potentially longer in elderly or renally impaired patients.

Absorption

Approximately 40-50% orally absorbed. Food can slightly delay time to peak concentration but does not significantly affect overall absorption.

Metabolism

Cefixime is not extensively metabolized in the body. No active metabolites have been identified.

Nifedipine

Concurrent use may increase cefixime bioavailability and peak plasma concentrations.

Probenecid

May decrease the renal excretion of cefixime, leading to increased and prolonged plasma concentrations.

Carbamazepine

Concomitant administration may increase carbamazepine plasma levels. Monitoring of carbamazepine levels should be considered.

Warfarin and other anticoagulants

May increase prothrombin time (INR) and risk of bleeding. Close monitoring is recommended.