Timozin
Generic Name
Timolol Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| timozin 10 mg syrup | ৳ 90.00 | N/A |
Description
Overview of the medicine
Timozin 10 mg Syrup contains Timolol Maleate, a non-selective beta-adrenergic blocker used to treat various conditions like hypertension, migraine prophylaxis, and certain types of angina.
Uses & Indications
Dosage
Adults
Initial dose is typically 10 mg orally once daily. Dosage may be increased to 20 mg/day or up to 60 mg/day in divided doses, depending on patient response and tolerability.
Elderly
Start with a lower dose (e.g., 5 mg once daily) and adjust gradually, monitoring for adverse effects.
Renal_impairment
No specific dose adjustment is usually required for mild to moderate renal impairment, but caution is advised. For severe impairment, close monitoring is necessary.
How to Take
Timozin syrup should be administered orally, with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Timolol Maleate blocks both beta-1 and beta-2 adrenergic receptors. This results in decreased heart rate, reduced myocardial contractility, and lowering of blood pressure. In migraine prophylaxis, it is thought to stabilize vascular tone.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour (oral administration), peak effect within 1-2 hours.
Excretion
Mainly through renal excretion (about 60-70% as metabolites, 20% as unchanged drug).
Half life
Approximately 2-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 50% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 2D6 (CYP2D6) isoenzyme.
Side Effects
Contraindications
- •Bronchial asthma or history of bronchial asthma
- •Severe chronic obstructive pulmonary disease (COPD)
- •Sinus bradycardia
- •Second- or third-degree atrioventricular block
- •Overt cardiac failure
- •Cardiogenic shock
Drug Interactions
Digitalis glycosides
Increased risk of additive bradycardia.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia, hypotension, and atrioventricular conduction disturbances.
CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
May increase plasma concentrations of timolol, enhancing its effects.
Catecholamine-depleting drugs (e.g., reserpine, guanethidine)
May have an additive effect, leading to excessive reduction of sympathetic activity, potentially causing hypotension and/or marked bradycardia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, and acute cardiac failure. Treatment is symptomatic and supportive, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Timolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
