Todol
Generic Name
Ketorolac Tromethamine
Manufacturer
General Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| todol 60 mg injection | ৳ 100.00 | N/A |
Description
Overview of the medicine
Todol 60 mg Injection contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderately severe acute pain.
Uses & Indications
Dosage
Adults
Initial dose 30 mg or 60 mg IM/IV, then 15-30 mg every 6 hours as needed, not exceeding 120 mg/day for IM/IV. Treatment duration should not exceed 5 days.
Elderly
Lower initial doses (e.g., 15 mg IM/IV every 6 hours) and reduced maximum daily dose (e.g., 60 mg/day).
Renal_impairment
Reduced dosage recommended (e.g., 15 mg every 6 hours), not exceeding 60 mg/day. Contraindicated in severe renal impairment.
How to Take
Administered intramuscularly (IM) or intravenously (IV). For IV administration, it should be given over at least 15 seconds.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by irreversibly blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby exerting its analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
Within 30 minutes (IM/IV)
Excretion
Mainly renal (over 90%), some fecal.
Half life
Approximately 4-6 hours
Absorption
Rapid and complete absorption after IM administration.
Metabolism
Primarily hepatic via hydroxylation and conjugation.
Side Effects
Contraindications
- •Hypersensitivity to ketorolac or other NSAIDs
- •Active peptic ulcer, recent GI bleeding or perforation
- •Severe renal impairment
- •Advanced renal disease
- •Coagulation disorders
- •Peri-operative pain in coronary artery bypass graft (CABG) surgery
- •Concomitant use with other NSAIDs, aspirin, probenecid, or pentoxifylline
Drug Interactions
Lithium
Increased lithium plasma levels
Warfarin
Increased risk of bleeding
Diuretics
Reduced diuretic effect, increased risk of renal impairment
Methotrexate
Increased methotrexate toxicity
ACE Inhibitors/ARBs
Reduced antihypertensive effect, increased risk of renal impairment
Aspirin/Other NSAIDs
Increased GI side effects, increased bleeding risk
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose include abdominal pain, nausea, vomiting, lethargy, and sometimes acute renal failure. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if recent oral ingestion, though less relevant for injection.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus (e.g., premature closure of ductus arteriosus). Use during lactation is generally discouraged as ketorolac passes into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired, available as generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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