Torped
Generic Name
Meropenem
Manufacturer
Example Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| torped 1 gm injection | ৳ 130.88 | N/A |
Description
Overview of the medicine
Meropenem is a broad-spectrum carbapenem antibiotic used to treat a wide variety of bacterial infections. It is administered intravenously and is effective against both Gram-positive and Gram-negative bacteria, including many anaerobic strains.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 gm intravenously every 8 hours, depending on the severity and type of infection. For meningitis or severe infections, 2 gm every 8 hours.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For CrCl 26-50 mL/min, 1 gm every 12 hours; for CrCl 10-25 mL/min, 500 mg every 12 hours; for CrCl <10 mL/min, 500 mg every 24 hours.
How to Take
Administer by intravenous bolus over 3-5 minutes or by intravenous infusion over 15-30 minutes.
Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to the disruption of the cell wall structure, resulting in bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV infusion.
Excretion
Primarily excreted unchanged by the kidneys (approximately 70% as unchanged drug) within 12 hours.
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapidly absorbed after intravenous administration, with 100% bioavailability.
Metabolism
Minimal hepatic metabolism; primarily hydrolyzed to an inactive metabolite by dehydropeptidase-I (though meropenem is relatively resistant to this enzyme compared to imipenem).
Side Effects
Contraindications
- Hypersensitivity to meropenem or any other carbapenem antibiotics.
- Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Competes with meropenem for active tubular secretion, resulting in increased plasma concentrations and prolonged half-life of meropenem.
Valproic Acid
Co-administration with meropenem may decrease valproic acid plasma concentrations, increasing the risk of seizures.
Oral Anticoagulants
Concomitant use with antibiotics, including meropenem, may enhance the anticoagulant effect of oral anticoagulants (e.g., warfarin).
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solution should be used immediately or within specified stability period.
Overdose
In case of overdose, discontinue meropenem and institute general supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Caution should be exercised when meropenem is administered to a nursing woman, as it is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to meropenem or any other carbapenem antibiotics.
- Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Competes with meropenem for active tubular secretion, resulting in increased plasma concentrations and prolonged half-life of meropenem.
Valproic Acid
Co-administration with meropenem may decrease valproic acid plasma concentrations, increasing the risk of seizures.
Oral Anticoagulants
Concomitant use with antibiotics, including meropenem, may enhance the anticoagulant effect of oral anticoagulants (e.g., warfarin).
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solution should be used immediately or within specified stability period.
Overdose
In case of overdose, discontinue meropenem and institute general supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Caution should be exercised when meropenem is administered to a nursing woman, as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check specific packaging for details.
Availability
Hospital and Retail Pharmacies
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Meropenem has undergone extensive clinical trials demonstrating its efficacy and safety across various severe bacterial infections. Ongoing post-marketing surveillance and new trials continue to refine its use.
Lab Monitoring
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC)
- Culture and susceptibility tests to confirm pathogen and guide therapy.
Doctor Notes
- Ensure appropriate culture and susceptibility testing is performed before initiating therapy, especially for empiric use.
- Monitor renal function carefully, particularly in elderly patients and those with pre-existing renal impairment, and adjust dosage accordingly.
- Be vigilant for CNS adverse effects, especially seizures, in patients with predisposing factors such as a history of epilepsy or impaired renal function.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if you feel better.
- Report any severe side effects, especially rash, difficulty breathing, or severe diarrhea, immediately to your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or seizures. Patients should be advised not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids unless advised otherwise by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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