Tracid
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Hypothetical Pharmaceuticals Inc.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tracid 650 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Tracid 650 mg tablet contains Paracetamol, which is used to relieve mild to moderate pain and reduce fever. It is one of the most commonly used pain relievers worldwide.
Uses & Indications
Dosage
Adults
Oral: 650 mg every 4-6 hours as needed. Do not exceed 4000 mg (4 grams) in 24 hours.
Elderly
No specific dosage adjustment usually required, but caution is advised in patients with impaired hepatic or renal function.
Renal_impairment
Dosage interval may need to be extended in severe renal impairment (e.g., every 8 hours for CrCl < 10 mL/min). Consult a doctor.
How to Take
Take the tablet orally with a glass of water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Paracetamol's exact mechanism is not fully understood but is thought to involve inhibition of prostaglandin synthesis in the central nervous system (CNS), leading to analgesic and antipyretic effects. It acts primarily by inhibiting cyclooxygenase (COX) enzymes, mainly COX-2, in the CNS.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesic/antipyretic effect.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1 to 3 hours in adults.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 to 60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 enzymes to a highly reactive intermediate (NAPQI), which is detoxified by glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or any component of the formulation
- •Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity with chronic high alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding. Monitor INR.
Cholestyramine
May decrease the rate of paracetamol absorption.
Metoclopramide, Domperidone
May increase the rate of paracetamol absorption.
Enzyme inducers (e.g., Carbamazepine, Phenytoin, Rifampicin)
May increase the risk of hepatotoxicity by increasing the formation of toxic paracetamol metabolites.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and sweating, which may progress to liver damage. In case of overdose, seek immediate medical attention. Treatment usually involves administration of N-acetylcysteine.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies, supermarkets, and general stores worldwide
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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