Tralin
Generic Name
Sertraline
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tralin 100 mg tablet | ৳ 7.03 | ৳ 70.30 |
Description
Overview of the medicine
Tralin 100 mg Tablet contains Sertraline, an antidepressant used to treat various mental health conditions including major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, and post-traumatic stress disorder.
Uses & Indications
Dosage
Adults
Initial: 50 mg once daily. May increase by 50 mg at weekly intervals up to a maximum of 200 mg once daily depending on response and tolerability.
Elderly
Similar to adult dosage, but start with a lower dose (e.g., 25 mg/day) and titrate carefully due to potential for decreased clearance and increased sensitivity.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment, consider lower initial doses.
How to Take
Tralin 100 mg Tablet should be taken orally, once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) in the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing its neurotransmission. This leads to an antidepressant and anxiolytic effect.
Pharmacokinetics
Onset
Antidepressant effects may take 2-4 weeks to become apparent, while anti-panic/anti-obsessive effects may take longer (up to 8-12 weeks).
Excretion
Mainly excreted in urine (about 40-45%) and feces (about 40-45%) as metabolites.
Half life
Approximately 26 hours for sertraline, and 62-104 hours for its active metabolite, N-desmethylsertraline.
Absorption
Well absorbed from the gastrointestinal tract, peak plasma concentrations reached within 4.5 to 8.4 hours. Food slightly increases absorption and reduces the time to peak plasma levels.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, CYP2B6, CYP2D6, CYP3A4, CYP2C9, and CYP3A5, to its major active metabolite, N-desmethylsertraline.
Side Effects
Contraindications
- •Hypersensitivity to sertraline or any component of the formulation
- •Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI
- •Concomitant use with pimozide
- •Concomitant use with disulfiram (for oral solution due to alcohol content)
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
Pimozide
Increased pimozide levels and cardiotoxicity.
Warfarin
Potentiation of anticoagulant effect, increased risk of bleeding.
NSAIDs/Aspirin
Increased risk of bleeding.
Tricyclic Antidepressants (TCAs)
Increased TCA levels.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Somnolence, vomiting, tachycardia, tremor, agitation, dizziness, coma (rare). Management: No specific antidote. Maintain airway, monitor cardiac and vital signs. Gastric lavage, activated charcoal, and symptomatic supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. SSRI use in late pregnancy may lead to withdrawal symptoms in neonates. Excreted in breast milk; use with caution during lactation, monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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