Trazapin
Generic Name
Trazodone Hydrochloride
Manufacturer
Reputable Pharmaceutical Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trazapin 30 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Trazodone is an antidepressant used to treat major depressive disorder. It also has sedative properties and is often used off-label for insomnia. The 30 mg strength is typically used for lower doses or initial titration.
Uses & Indications
Dosage
Adults
For depression: Initial dose 50-150 mg/day in divided doses. May increase to 400 mg/day for outpatients, 600 mg/day for inpatients. For insomnia: 25-100 mg at bedtime.
Elderly
Start with lower doses, e.g., 25-50 mg/day, due to increased sensitivity and potential for orthostatic hypotension.
Renal_impairment
No specific dosage adjustment for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, usually after a meal or light snack to reduce dizziness and increase absorption. If used for insomnia, take at bedtime.
Mechanism of Action
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It selectively inhibits serotonin reuptake and acts as an antagonist at 5-HT2A and alpha1-adrenergic receptors. These actions contribute to its antidepressant, anxiolytic, and sedative effects.
Pharmacokinetics
Onset
Sedative effects may appear within hours. Antidepressant effects typically take 2-4 weeks to become apparent.
Excretion
Approximately 75% excreted in urine, 25% in feces within 72 hours.
Half life
Biphasic elimination: initial half-life of 3-6 hours, terminal half-life of 5-9 hours.
Absorption
Well absorbed orally. Food significantly increases absorption (up to 2-fold) and decreases peak plasma concentrations, which may reduce side effects like dizziness.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, to an active metabolite (m-chlorophenylpiperazine, m-CPP) and other inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to trazodone or any component of the formulation.
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- •Acute recovery phase of myocardial infarction.
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
Warfarin
Increased prothrombin time/INR.
Digoxin/Phenytoin
Increased plasma levels of digoxin or phenytoin.
CNS Depressants (e.g., alcohol, benzodiazepines)
Additive CNS depressant effects.
CYP3A4 Inducers (e.g., carbamazepine, phenytoin)
Decreased plasma concentrations of trazodone.
CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
Increased plasma concentrations of trazodone.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, dizziness, nausea, vomiting, priapism, respiratory arrest, and seizures. Management is supportive, including gastric lavage or activated charcoal if appropriate, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Not recommended during breastfeeding as trazodone is excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Off-patent
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Global Brand Names
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