Trevox
Generic Name
Levofloxacin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trevox 500 mg tablet | ৳ 17.00 | ৳ 170.00 |
| trevox 500 mg injection | ৳ 100.30 | N/A |
Description
Overview of the medicine
Trevox (Levofloxacin) is a synthetic, broad-spectrum antibacterial agent of the fluoroquinolone class. It is used to treat various bacterial infections including respiratory tract, skin and soft tissue, urinary tract, and intra-abdominal infections.
Uses & Indications
Dosage
Adults
250 mg to 750 mg orally or intravenously once daily, depending on the type and severity of infection.
Elderly
No specific dose adjustment is required based solely on age, but renal function should be assessed and dose adjusted accordingly.
Renal_impairment
Dosage adjustment is necessary in patients with impaired renal function (creatinine clearance <50 mL/min) to prevent drug accumulation.
How to Take
Oral tablets can be taken with or without food. The intravenous solution should be administered slowly by infusion over a period of 60 to 90 minutes.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Onset of action within 1-2 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine, mainly via glomerular filtration and tubular secretion.
Half life
Approximately 6 to 8 hours.
Absorption
Rapid and nearly complete oral absorption, with peak plasma concentrations typically achieved within 1-2 hours. Oral bioavailability is approximately 99%.
Metabolism
Minimally metabolized in the liver; less than 5% of a dose is recovered in the urine as metabolites.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Epilepsy.
Drug Interactions
NSAIDs
Concomitant use with NSAIDs may increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing bleeding risk.
Corticosteroids
Increased risk of tendon rupture when co-administered.
Antacids (Mg/Al), Sucralfate, Iron, Zinc
May reduce oral absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. ECG monitoring should be performed due to the potential for QT interval prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and therefore not recommended during breastfeeding due to potential for serious adverse reactions in nursing infants.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Epilepsy.
Drug Interactions
NSAIDs
Concomitant use with NSAIDs may increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing bleeding risk.
Corticosteroids
Increased risk of tendon rupture when co-administered.
Antacids (Mg/Al), Sucralfate, Iron, Zinc
May reduce oral absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. ECG monitoring should be performed due to the potential for QT interval prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and therefore not recommended during breastfeeding due to potential for serious adverse reactions in nursing infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when stored under recommended conditions.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA/FDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Levofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests
- Liver function tests
- Blood glucose monitoring (especially in diabetic patients)
- ECG monitoring (in patients with risk factors for QT prolongation)
Doctor Notes
- Counsel patients on the importance of completing the full course to prevent resistance.
- Advise patients to report any signs of tendinitis (pain, swelling in joints), neuropathy (tingling, numbness), or CNS effects (confusion, seizures) immediately.
- Monitor renal function, especially in elderly patients and those with pre-existing renal impairment.
- Be aware of potential for QT interval prolongation in susceptible patients.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you feel better.
- Avoid prolonged exposure to sunlight or artificial UV light, and use sunscreen and protective clothing.
- Report any pain, swelling, or inflammation of a tendon immediately to your doctor.
- Do not take antacids containing magnesium or aluminum, sucralfate, iron, or zinc supplements within 2 hours of taking levofloxacin.
- Stay well-hydrated.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Levofloxacin may cause dizziness, lightheadedness, visual disturbances, or confusion. Patients should be advised to know how they react to the drug before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Ensure adequate fluid intake.
- Avoid self-medication and always consult a doctor before starting or stopping any medication.
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