Adults

Typically 1-2g once daily, administered IM or IV.

Elderly

No specific dose adjustment needed based on age alone, but renal function should be considered.

Renal_impairment

Dosage adjustment may be necessary in severe renal impairment. Consult prescribing information.

Onset

Typically within 30 minutes to 2 hours.

Excretion

Approximately 50-60% excreted unchanged in urine, 40-50% in bile and feces.

Half life

Approximately 5.8 to 8.7 hours.

Absorption

Rapidly and completely absorbed after intramuscular (IM) injection.

Metabolism

Primarily undergoes non-enzymatic degradation in the gut, minimal hepatic metabolism.

Oral anticoagulants

Increased risk of bleeding.

Calcium-containing solutions

Should not be administered simultaneously with ceftriaxone, especially in neonates.