Triocim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triocim 100 mg suspension | ৳ 210.00 | N/A |
Description
Overview of the medicine
Cefixime is a broad-spectrum antibiotic from the cephalosporin class, used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Not typical for 100 mg suspension. For Cefixime tablets, 200-400 mg daily as a single dose or in two divided doses.
Children
8 mg/kg/day in a single dose or two divided doses for children aged 6 months to 12 years. (100 mg/5 ml suspension is often 5 ml for 10-15 kg child)
Renal_impairment
Dosage adjustment required. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Administer orally with or without food. Shake the bottle well before each use to ensure uniform dosing. Use the provided measuring device for accurate dosage.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily via kidney (about 50-60% unchanged in urine); some biliary excretion.
Half life
3-4 hours
Absorption
Approximately 40-50% absorbed orally. Food may delay but not significantly alter absorption.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of hypersensitivity to penicillins (due to potential for cross-reactivity).
Drug Interactions
Warfarin
May increase anticoagulant effect (monitor INR).
Carbamazepine
May increase carbamazepine levels.
Oral Contraceptives
May reduce efficacy (advise additional contraception).
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard after 7-14 days as per product specific guidelines. Do not freeze.
Overdose
Gastric lavage, symptomatic and supportive treatment. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B: Animal studies show no risk, but human studies are limited. Use only if clearly needed. Lactation: Excreted in small amounts in breast milk; generally considered safe, but monitor infant for diarrhea or thrush.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporin antibiotics.
- History of hypersensitivity to penicillins (due to potential for cross-reactivity).
Drug Interactions
Warfarin
May increase anticoagulant effect (monitor INR).
Carbamazepine
May increase carbamazepine levels.
Oral Contraceptives
May reduce efficacy (advise additional contraception).
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard after 7-14 days as per product specific guidelines. Do not freeze.
Overdose
Gastric lavage, symptomatic and supportive treatment. Hemodialysis or peritoneal dialysis is not effective in removing Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B: Animal studies show no risk, but human studies are limited. Use only if clearly needed. Lactation: Excreted in small amounts in breast milk; generally considered safe, but monitor infant for diarrhea or thrush.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As indicated on the packaging (typically 2-3 years for dry powder). Reconstituted suspension has a shorter shelf life, usually 7-14 days when refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for treating various bacterial infections in both adults and pediatric populations.
Lab Monitoring
- Renal function (especially in patients with pre-existing renal impairment).
- Liver function (in prolonged therapy).
- Coagulation parameters (if co-administered with anticoagulants).
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
- Advise parents/caregivers on proper measurement and administration techniques for pediatric patients.
- Counsel patients on potential gastrointestinal side effects and what to do if they occur.
Patient Guidelines
- Complete the full course of antibiotics as prescribed by your doctor, even if symptoms improve.
- Shake the suspension bottle well before each use.
- Use the provided measuring cup or syringe for accurate dosing, especially for children.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness; patients should avoid driving or operating machinery if they experience this side effect.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids, especially if experiencing diarrhea.
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